Editor Name: Dr. Amanjot Kaur Riar
Educational Qualification: PhD
Designation: Research Scientist
Department: Department of Medicine,
University: Brigham and Women’s Hospital
Research Interest: Fetal Alcohol Syndrome Amyotrophic Lateral Sclerosis (ALS) Neurosciences Cancer Biology Environmental toxicology Neurobiology Neurogenesis Cerebral cortex Mitochondrial biology Unfolded protein response Substance Abuse Protein misfolding Signal transduction Gene expression Cell cycle Mucosal immunology
Biography: I joined Brigham and Women’s Hospital (BWH), Harvard affiliated hospital as a Research Manager in the Department of Medicine in 2016. Prior to coming to BWH, I worked as a Senior Research Associate at Mount Sinai School of Medicine, New York. I received B.S in Pharmacy from India and Ph.D. and MBA from Texas Tech University Health Sciences Center, Texas, USA. During my doctoral training, my research project was focused on exploring the molecular mechanisms underlying abnormal neurogenesis in fetal alcohol syndrome. I investigated the effect of ethanol on Tbr2-positive basal progenitor cell proliferation which populate the cortical layers and conversely the mechanism of alcohol-induced cerebral cortex abnormalities resulting from impaired proliferation. I have shown that ethanol inhibits the proliferation of basal progenitors through altering the expression of cell cycle proteins. My studiesalso revealed that ethanol alters the activity of glycogen synthase kinase 3? (GSK-3?) signaling pathway in central nervous system, where it is predominantly found and modifies various neurogenetic processes by regulating downstream targets. My postdoctoral research involved understanding the role of mitochondrial unfolded protein response (UPR) in SOD1-G93A model of amyotrophic lateral sclerosis (ALS). I investigated the intermembrane space (IMS)-UPRmt in G93A-SOD1mousemodel of familialALS, sincemutant SOD1 is known to accumulate in the IMS of neural tissue and cause mitochondrial dysfunction.Using a mouse model in which G93A-SOD1 was selectively targeted to the IMS, I demonstrated that the IMS-UPRmt could be specifically initiated by mutant SOD1 localized in the IMS.
1. A.K.Riar, S.R Burstein, G.Palomo, A Arreguin, G Manfredi. D Germain. Sex specific activation of the ERα axis of the mitochondrial UPR in the G93A-SOD1 mouse of familial ALS. FASEB mitochondrial conference, 2017
2. A.K.Riar, M.Narsimhan, M.L.Rathinam, D.Vedpathak, G.I.Henderson, L.Mahimainathan (2013). Ethanol Transcriptionally Activates Programmed Cell Death 4 (PDCD4) in Rat Cortical Brain Neuroblasts. Abstracts–Posters. Alcoholism: Clinical and Experimental Research, 37: 11A–253A.
3. A.Riar, M.Narasimhan, M.L.Rathinam, D.Vedpathak, D.Patel, G.Henderson, L.Mahimainathan (2012). Role of Programmed Cell Death 4 (PDCD4) in Ethanol-Induced Dysregulation of Neurogenesis. Abstracts— Posters. Alcoholism: Clinical and Experimental Research, 36: 11A–303A.
4. A.Riar, M.Narasimhan, M.L. Rathinam, G.I. Henderson and L. Mahimainathan (2013). Ethanol Inhibits the Proliferation of Cortical Basal Neuronal Progenitors.
5. A.Riar, M.Narasimhan, M.L. Rathinam, G.I. Henderson and L. Mahimainathan (2012). Role of Programmed Cell Death 4 (PDCD4) In Ethanol-Induced Dysregulation of Neurogenesis. Texas Research Society on Alcoholism (TRSA) combined with Texas American Society of Addiction Medicine (TSAM) and Region 8 American Association of Addiction Psychiatry (AAAP), Bryan/College Station, Texas
6. A.Riar, M.Narasimhan, M.L. Rathinam, G.I. Henderson and L. Mahimainathan (2011). Programmed Cell Death 4 (PDCD4) As A Potential Mediator of Ethanol Induced Inhibition of Neuroblast Proliferation. Texas Research Society on Alcoholism (TRSA), Lubbock, Texas.
7. ML Rathinam, M Narasimhan, AK Riar, GI Henderson, L Mahimainathan (2013). Ethanol induces oxidative modification of DJ-1 CYS 106 influencing intracellular glutathione in neurons. Alcoholism: Clinical and Experimental Research, 37: 190A–190A
8. M Narasimhan, ML Rathinam, D Vedpathak, AK Riar, GI Henderson, L Mahimainathan (2013). Interaction of MIR153 & MIR27A-NRF2/ARE pathway during neuronal oxidative stress. Alcoholism: Clinical and Experimental Research, 37: 126A–126A
9. ML Rathinam, M Narasimhan, A Fowler, A Riar, BS Kasturi, L Mahimainathan, GI Henderson (2011). Ethanol dysregulates transulfuration pathway in primary cortical neurons (PCN). Alcoholism: Clinical and Experimental Research, 35 (6), 37A-37A
1. Riar AK, Burstein SR, Palomo GM, Arreguin A, Manfredi G, Germain D. Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS. Hum Mol Genet. 2017 Apr 1;26(7):1318-1327
2. T C Kenny, P Hart, M Ragazzi, M Sersinghe, J Chipuk, M A K Sagar, K W Eliceiri, T LaFramboise, S Grandhi, J Santos, A K Riar, L Papa, M D'Aurello, G Manfredi, M G Bonini and D Germain. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis. Oncogene. 2017 April 3; 36, 4393–4404
3. Riar AK, Narasimhan M, Rathinam ML, Henderson GI, Mahimainathan L. Ethanol induces cytostasis of cortical basal progenitors. J Biomed Sci. 2016 Jan 19; 23(1)
4. Riar AK, Kenny TC, Takabatake Y, Papa Luena, Germain D. Mitochondrial dysnfunction in breast cancer. Research and Reports in Biology - Dove Medical Press (2015)
5. Riar AK, Narasimhan M, Rathinam ML, Vedpathak D, Mummidi S, Henderson GI, Mahimainathan L. Ethanol-Induced Transcriptional Activation of Programmed Cell Death 4 (Pdcd4) Is Mediated by GSK3beta Signaling in Rat Cortical Neuroblasts. PloS one 2014, 9(5): e98080.
6. Narasimhan M, Riar AK, Rathinam ML, Vedpathak D, Henderson G, Mahimainathan L. Hydrogen Peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxocity. Toxicol Lett. 2014 Aug 4;228(3):179-91.
7. Narasimhan M, Rathinam M, Riar A, Patel D, Mummidi S, Yang HS, Colburn NH, Henderson GI, Mahimainathan L. Programmed cell death 4(PDCD4): a novel player in ethanol-mediated suppression of protein translation in primary cortical neurons and developing cerebral cortex. Alcohol Clin Exp Res.2013 Jan; 37(1): 96-109
8. Rathinam ML, Watts LT, Narasimhan M, Riar AK, Mahimainathan L, Henderson GI. Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat. Environ Toxicol Pharmacol.2012 Mar;33(2):353-60
9. Narasimhan M, Mahimainathan L, Rathinam ML, Riar AK, Henderson GI. Overepression of Nrf2 protects cerebral cortical neurons from ethanol-induced apoptotic death. Mol.Pharmacol.2011 Dec; 80 (6): 988-99