Editor Name: Dr. Gaurav Mehta
Educational Qualification: PhD
Designation: Research Scientist
Department: Department of Cancer Biology,
University: The University of Toledo
Research Interest: Molecular Biology, Biochemistry and Cancer Biology
Biography: Dr. Gaurav Mehta received his PhD degree in Biochemistry and Cancer Biology from The University of Toledo, Ohio in 2015 and is currently a Postdoctoral fellow at the Rutgers Cancer Institute of New Jersey (CINJ). His research focuses on understanding the epigenetic and non-epigenetic mechanisms involved in the development of Triple Negative Breast Cancer (TNBC) using multi-omics data from The Cancer Genome Atlas (TCGA) project and integrate it with the molecular biology approach to identify genomic alterations involved in the regulation of PI3K/Akt signaling in TNBC. His research work has been published in several high-profile journals including Nucleic Acid Research, Oncoimmunology, Journal of Molecular and Cellular Cardiology, Breast Cancer Research and Treatment and he has also been a recipient of numerous awards including the Gallo award for Outstanding Researcher and the prestigious New Jersey Commission on Cancer Research (NJCCR) Postdoctoral fellowship award.
1. Mehta G., Tare M., Menon G., (2010). Phytochemical, Anti-Microbial and Antioxidant Evaluation of Dendrophthoe falcata (L.f.) Ettingsh Leaves. Indian Journal of Applied and Pure Biology. 25 (2): 285-292.
2. Marathe, H. G., Mehta G., Zhang, X., Datar, I., Mehotra, A., Yeung, K. C., and de la Serna, I. L. (2013). SWI/SNF enzymes promote SOX10- mediated activation of myelin specific gene expression. PLOS ONE. 8(7): e69037.
3. Mehrotra A., Mehta G., Aras S., Trivedi A., de la Serna I. (2014). SWI/SNF Chromatin Remodeling Enzymes in Melanocyte Differentiation and Melanoma. Crit Rev Eukaryot Gene Expr. 24(2): 151-61. (Featured as the cover article)
4. Mehta G., Kumarasamy S., Wu J., Walsh A., Liu L., Williams K., Joe B., de la Serna I.L (2015). MITF interacts with the SWISNF subunit, BRG1 to promote GATA4 expression in cardiac hypertrophy. J Mol Cell Cardiol. 88: 101-110.
5. Mehta G., Parker J.S., Silva G.O., Hoadley K.A., Perou C.M., Gatza M.L. Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer (2017). Breast Cancer Research and Treatment. 162 (3): 439-450.
6. Marathe H.G., Chow D.E., Weider M., Mehta G., Trivedi A., Aras S., Basuroy T., Mehrotra A., Wegner M., Pavan W.J., de la Serna, I.L. Brg1 interacts with Sox10 to establish the melanocyte lineage and to promote differentiation (2017). Nucleic Acid Research. 45 (11): 6442-6458.
7. Thomas A., Routh E.D., Pullikuth A., Jin G., Su J., Chou J.W., Hoadley K.A., Print C., Knowlton N., Black M.A., Demaria S., Wang E., Bedognetti D., Jones W.D., Mehta G., Gatza M.L., Perou C.M., Page D.B., Triozzi P., Miller L.D. Tumor mutational burden is a determinant of immune-mediated survival in breast cancer (2018). Oncoimmunology. e1490854-2.
Manuscripts in Preparation
1. Mehta G., de la Serna, IL. Protein Arginine methyltransferase–5 (PRMT5) promotes melanocyte differentiation.
2. Morgan E., Mehta G., Zhao X., de la Serna I.L., Liu L. Ouabain induced Akt signaling is preserved in pressure-overload induced compensated hypertrophy.
3. Angus SP, Stuhlmiller TJ, Mehta G., Tanioka M, Zawistowski JS, Sciaky N, Chen X, Bevill SM, He X, Rashid N, Chollett-Hinton L, Jefferys S, Hoadley KA, Parker JS, Gallagher KK, Forero A, Krop IE, Thompson AM, Murthy R, Gatza ML, Perou CM, Earp HS, Carey LA, Johnson GL. FOXA1 is a critical adaptive response determinant to targeted therapy in HER2-positive breast cancer.
Presentations Invited Oral Presentations
1. Invited speaker at the Annual Retreat on Cancer Research in New Jersey, New Jersey. May 25, 2017. Title of the talk: “An integrated genomics approach identifies BRG1 and SOX4 as genetic drivers of PI3K/Akt signaling in breast cancer”.
2. Invited speaker at the Canadian Cardiovascular Congress (CCC), Vancouver, Canada. October 25-28, 2014. Title of the talk: “SWISNF chromatin remodeling enzymes in transcriptional regulation of pathological cardiac hypertrophy”.
3. Invited speaker at the University of Toledo, College of Medicine, OH. March 18, 2014. Title of the talk: “SWISNF chromatin remodeling enzymes in transcriptional regulation of pathological cardiac hypertrophy”.
4. Invited speaker at the Physiology and Pharmacology Colloquium, Wayne State, Michigan. June 7, 2013. Title of the talk: “SWISNF chromatin remodeling enzymes in transcriptional regulation of pathological cardiac hypertrophy”.
5. Invited speaker at the UT Midwest Graduate Research Symposium held at the University of Toledo, OH. March 29, 2013. Title of the talk: “SWISNF chromatin remodeling enzymes in transcriptional regulation of pathological cardiac hypertrophy”.
6. Invited speaker at the 34th Annual Asilomar Chromatin and Chromosome conferences, California, December 13-16, 2012. Title of the talk: “SWISNF chromatin remodeling enzymes in transcriptional regulation of pathological cardiac hypertrophy”.
Selected Poster Presentations
1. Mehta G., Khella C., Angus SP, Johnson GL and Gatza ML. Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer by regulating TGFBR2 expression. The 2018 Annual Retreat on Cancer Research in New Jersey, May 24, 2018.
2. Mehta G., Khella C., Angus SP, Johnson GL and Gatza ML. Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer by regulating TGFBR2 expression. American Association for Cancer Research (AACR) annual meeting, Chicago, IL, April 14-18, 2018.
3. Mehta G., de la Serna IL. Protein arginine N-methyltransferase-5 (PRMT5) in melanocyte differentiation. 18th annual meeting of PanAmerican Society for Pigment Cell Research (PASPCR), University of Wisconsin, Madison, September 8-11, 2013