Abstract:

Since most of the standard anticancer treatments are not selective and affect both tumor and normal cells, thereby causing systemic toxicity or increased risk of other cancers. Thus, there is a need for the development of safer alternatives for the treatment of cancer which are affordable, accessible, having less toxicity and minimum side effects. This paper is carried out to investigate the anticancer MCF7 (breast cancer), Hela (cervical cancer) cell line, antioxidant (Iron chelating properties and Chemiluminescence   assay), cytotoxicity activities and Phytochemical investigation Sudanese medicinal plant A. arabica leaves and gum.

Plant parts were extracted using 80% methanol. The anticancer activity was examined by using MTT assay. And determine their antioxidant activities, screened for their cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium    bromide (MTT), filter and kept in dark, prepared freshly. 

The extract A. arabica gum is showed high activity against Chemiluminescence   assay IC50 values  27.3 μg/ml. and no activity in leaves > 100 μg/ml,  antioxidant (Iron chelating properties) no activity levels of inhibition %   in   A. arabica gum 11.92 μg/ml. The methanol extracts of the  plant showed considerable activity against MCF7 (Breast cancer) according to the inhibition percentage A. arabica Gum. Also A. arabica leaves and  gum against Hela (cervical cancer) cell line no activity IC50 values   > 100 μg/ml,

Phytochemical, screening of the extracts A. Arabica leaves indicated presence of alkaloids, cumarin, triterpenes, saponins in trace amount, and sterols in moderate amount, and tannins, flavonoids in high amount, and anthraquenones were not detected. A. Arabica gum indicated presence of alkaloids, cumarin in trace amount, and triterpenes in moderate amount, and tannins, flavonoids, sterols, saponins in high amount, and anthraquenones were not detected.