Abstract:

Plants have been used in treating human diseases for thousands of years; Sudanese medicinal plants used locally in traditional medicine to treat wide range of diseases were investigated for their anticancer, antioxidant activities and Cytotoxicity. This work was carried out to investigate the anticancer, antioxidant and Cytotoxicity activities of four Sudanese medicinal plants commonly used as anti-inflammatory and anti tumor. Hibiscus sabdariffa L fruits, Sonchus oleraceus L.leaves, Halexylon salicornietum (MAB) whole plant, Prosopis juliflora (SW.) DC leaves. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against PC3 (prostate cancer) cell lines. and determine their antioxidant activities by testing Chemiluminescence activity, screened for their cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium    bromide (MTT), filter and kept in dark, prepared freshly. The extract Prosopis juliflora (SW.) DC is showed very high against-PC3 and Hibiscus sabdariffa is showed high against-PC3  the extract of  Halexylon salicornietum and Sonchus oleraceus L is showed none active anti- PC3 with IC50 values  30.1 ,  94.7, > 100, and > 100 μg/ml respectively. All the extracts revealed cytotoxicity activity against Vero cell line except last concentration in extract of Sonchus oleraceus L, and the inhibition percentage with (90.56,87.12,86.24) (82.78,82.31,77.38) (75.21,59.49,41.24) (74.93,73.78,71.13) respectively. The extracs of  Hibiscus sabdariffa, Halexylon salicornietum and Sonchus oleraceus L. are revealed low active against Chemiluminescence   assay, Prosopis juliflora (SW.)DC is revealed  high active against Chemiluminescence   assay.with IC50 values   166.6, 189.5, > 176.2 and 75.4 μg/ml respectively.