Abstract:

Cancer is a class of diseases characterized by out of control cell growth and behavior; Plants have been used in treating human diseases for thousands of years. Since prehistoric times, shamans or medicine men and women of European, Africa, Asia and the Americas acquired a tremendous knowledge of medicinal plants. This paper is carried out to investigate the prostate cancer, antioxidant and cytotoxicity activities of some Sudanese medicinal plants. A. arabica leaves and gum, A. mellifera leaves, C. cajan leaves, T. foenum graecum L. Seeds. All the plant parts were extracted using 80% methanol. The anticancer activity was examined by using MTT assay against PC3 (prostate cancer) cell lines and determine their antioxidant activities by testing DPPH activity, screened for their cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium    bromide (MTT), filter and kept in dark, prepared freshly.  The extract A. arabica gum and leaves has shown very high activity against-PC3 and the extract  C. cajan leaves and T. foenum graecum L and  A. mellifera leaves is shown  none active anti- PC3 with IC50 values   39.4, 64.9, > 100, > 100 and  > 100 μg/ml respectively. All the extract revealed cytotoxicity activity against Vero cell line were found of no cytotoxicity and the inhibition percentage with (58.9, 49.6, 34.5) (- 69.27, - 37.26, -17.32) (87.3, 71.7, 66.6) (-48.03,-46.2, 3.7) respectively. The extract shown very high activity against DPPH (above 80%)  A. arabica gum 91.81, A. mellifera leaves 87.64 μg/ml.