Abstract:

Zinc-dependent autolysin amidase induced bacterial vaccine may construct to be designed for AmiA, AmiB, and AmiC against Escherichia coli, and LytA against Steptococcus pneumoniae. Zinc-dependent autolysin endopeptidase induced vaccine may be considered for D, D-endopeptidase regulation against Gram-negative Vibrio cholerae. Zinc-dependent autolysin carboxypeptidase induced vaccine also appears to be effective for TBVs against malaria eradication. The anti-bacterial vaccine activity of released Zn²⁺ ion occurs by zinc-mediated autolysin induced bacteriolyses.

The ability to create ZFN vaccine that can prevent and eliminate persistent viral infections is a long way from being realized. The efficacies by available LAV, live-attenuated rotavirus, influenza, and varicella zoster vaccines are strong incentive to redouble efforts to improve the safety characteristics of this type of vaccine. Vaccines for numerous infectious diseases have been developed using whole inactivated virions. ZOTENs prevent HSV-2 infection and disease with providing a platform for virus capture and presentation of neutralized virions. The anti-viral vaccine activity may arise by zinc-mediated adapted immunity, viral apoptosis and death.

ZNF165 is novel cancer testis antigen capable of eliciting humoral immune response. ZNF165 induced HCC vaccine could be achieved as involved in tumor biology. ZMCs cancer vaccines have small molecular metal ion chelators and can be developed as the cancer therapeutics. MMP-2 may play a key role in angiogenesis and tumor growth that the vaccine based on chicken homologous MMP-2 as a model antigen could induce both protective and therapeutic antitumor immunity. The anti-cancer vaccine activity may result by inhibition of tumor development, subsequently arising in the increase of cell-mediated immunity, and tumorous necrosis cell death. Hence, these novel targeted cancer therapeutics will be applied to cancer or tumor vaccine in future.