Abstract:

M?nuka honey 10+ is a  honey produced from the nectar of the m?nuka tree, Leptospermum scoparium. It is collected by honeybees foraging on its tree, which grows in New Zeland and Australia. This honey is commonly sold as a supplement, or alternative medicine. While several components in m?nuka honey are studied for their potential bactericidal properties vivo. Superantigens toxins produced by Staphylococcal aureus have caused the heart valves functioning and kills thousands American every year on bacterial complication Infective Endocarditis (IE). This endotoxin is causing extensive activation of inflammatory cells; patients may present nonspecifically with fever, weight loss but not limited to other immunological reactions and hemorrhagic reaction. Complications in the form of systemic emboli from vegetation fragments can damage blood vessels within various organs, including brain, eye, spleen, kidney, pulmonary, and heart. Honey has broad spectrum antimicrobial bacteria activity specifically for staph bacteria due to its high osmolarity and high concentration of hydrogen peroxide. There is a synergistic potential action in treating wounds by combine both oxacillin and manuka honey against MRSA (methicillin-resistant Staphylococcus aureus). Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family) is commonly called “turmeric”, has used widely for cooking in Asian cuisine. At relatively nontoxic dose, it is known to be effective against Staphylococcus aureus (S. aureus). In vivo, turmeric powder will exhibit more potency effect when it used in combination with other IV antibiotic. Interestingly, paring of IV antibiotic regimen, manuka honey 10+ combine with turmeric powder might kill bacterial Staph Auerus Complicated Infective Endocarditis (IE) infection naturally.