Manuscript for Review Process
The Diagnosis and Management of Parkinson’s disease
Abstract:
Parkinson's disease is the second commonest neurodegenerative disorder, after Alzheimer's, and represents a major cause of neurological morbidity globally. The diagnosis is made clinically and management is currently restricted to symptomatic treatments, with levodopa continuing to form the cornerstone of pharmacological therapy. Deep brain stimulation of specific basal ganglia targets can offer significant symptomatic benefits in selected patient groups. To date, no established disease-modifying agents that can halt or reverse the underlying neurodegenerative process are available in clinical practice. The aim of this article is to provide an overview, and an update, on the diagnosis and management of Parkinson's disease.
Keywords:
Parkinson’s disease, bradykinesia, rigidity, tremor, dyskinesia, levodopa, dopamine receptor agonists, deep brain stimulation.