Dr. Jatin Machhi

Journal of Biomedical Research and Reviews

Department of Pharmacology and Experimental Neuroscience

Name: Dr. Jatin Machhi

Educational Qualification: Ph.D.

Designation: Instructor at University of Nebraska Medical Center, Omaha, USA

Department: Department of Pharmacology and Experimental Neuroscience

University: University of Nebraska Medical Center

Email: jtnmachhi@gmail.com

Research Interests: Pharmacology, Immunology, Neuroscience

Biography: Dr. Machhi is an Instructor at the University of Nebraska Medical Center. He completed his education from the reputed institutes of the India include Bachelor of Pharmacy from the Sardar Pater University, Master of Pharmacy from the Gujarat Technological University and Ph.D. from the Maharaja Sayajirao University of Baroda. He also served as a postdoctoral research associate at the University of Nebraska Medical Center. Dr. Machhi is a highly experienced and dedicated professional with eight years of research experience in pharmacology, neuroimmunology and neurodegenerartive diseases including Alzheimer’s and Parkinson’s disease. Also experienced in studying HIV pathogenesis and antiretroviral drug biodistribution up to cellular level. Currently working on development of T cell immune therapies for the potential treatment of neurodegenerative diseases. Also developing next-generation mouse models of Alzheimer’s disease using CRISPR-Cas9 technology.

Patent

Mange Ram Yadav, Mahesh Shidore, Jatin Machhi, Prashant Murumkar, Rajani Giridhar. 3-Benzazapine-2-one derivatives as 5-HT 2C receptor agonists and the process for their preparation.

Indian Patent, Appl./959/MUM/2015

Served as reviewer in journals

Journal of Neuroimmune Pharmacology (Springer)
BMC Immunology (BMC)
Translational Neurodegeneration (BMC)
Journal of International Medical Research (Sage)
Bioorgenic Chemistry (Elsevier)
Americal Journal of Nanomaterials
Journal of Neuroscience and Neurological Surgery
Acta Scientific

Editorial Board Member

Journal of Neuroimmune Pharmacology (Editor-in-training, Springer)
Acta Scientific Neurology
Journal of Neuroscience and Neurological Surgery
American Journal of Psychiatry and Neuroscience

Jatin Machhi et al., (2021) Nanocarrier Vaccines for SARS-CoV-2. Advanced Drug Delivery Reviews (in press)
Jatin Machhi et al., (2021) A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention. Journal of Neuroimmune Pharmacology (in press)
Bhavesh Kevadiya, Jatin Machhi et al., (2020) Diagnostics for SARS-CoV-2 Infections. Nature Materials (in press).
Bhavesh Kevadiya, Jatin Machhi et al., (2020) Pharmacotherapeutics of SARS-CoV-2 Infections. Journal of Neuroimmune Pharmacology (in press).
Jatin Machhi et al., (2020) The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections. Journal of Neuroimmune Pharmacology 21, 1-28.
Jatin Machhi, Bhavesh Kevadiya, Ijaz Khan Muhammad, et al., (2020) Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders. Molecular Neurodegeneration 15 (1), 32.
Insiya Z. Mukadam, Jatin Machhi, et al., (2020) Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking. Biomaterials 231, 119669.
Aaron D. Schwab, Mackenzie J. Thurston, Jatin Machhi, et al., (2020) Immunotherapy for Parkinson's disease. Neurobiology of Disease, 137, 104760.
Bhavesh D Kevadiya, Brendan Ottemann, Insiya Z Mukadam, Laura Castellanos, Kristen Sikora, James R Hilaire, Jatin Machhi, et al., (2020) Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Theranostics 10 (2), 630.
R. L. Mosley, Yaman Lu, Katherine E. Olson, Jatin Machhi, et al., (2019) A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease. Frontiers in Cellular Neuroscience 13, 421.
Tomomi Kiyota, Jatin Machhi* et al., (2018) URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease. Journal of neuroinflammation 15 (1), 137 (*Shared first author).
Tomomi Kiyota, Jatin Machhi et al., (2018) Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice. Journal of neuroimmunology 319, 80-92.
Mayank K. Sharma, Jatin Machhi et al., (2018) New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents. Scientific reports 8 (1), 1-18.
Midhun B Thomas, Divya Prakash Gnanadhas, Prasanta K Dash, Jatin Machhi et al., (2018) Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine 13 (17), 2139-2154.
Jatin Machhi et al., (2017) Synthesis and biological evaluation of novel multi-target-directed benzazepines against excitotoxicity. Molecular neurobiology 54 (9), 6697-6722.
Ragitha Chruvattil, Shreya Banerjee, Sarmi Nath, Jatin Machhi et al., (2017) Dexamethasone alters the appetite regulation via induction of hypothalamic insulin resistance in rat brain. Molecular neurobiology 54 (9), 7483-7496.
Jatin Machhi et al., (2016) Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer’s Disease Through Activation of Canonical Wnt/β-Catenin Signalling Pathway. Neurotoxicity research 29 (4), 495-513.
Mahesh Shidore, Jatin Machhi* et al., (2016) Benzylpiperidine-linked diarylthiazoles as potential anti-Alzheimer’s agents: synthesis and biological evaluation. Journal of medicinal chemistry 59 (12), 5823-5846 (*Shared first author).
Neetesh Agrawal, Jatin Machhi et al., (2016) Exploration of 6,7-dimethoxyquinazoline derivatives as dual acting α1- and AT1-receptor antagonists: synthesis, evaluation, pharmacophore & 3D-QSAR modeling and receptor docking studies. RSC advances 6 (36), 30661-30682.
Jatin Machhi et al., (2015) D3 Antagonist and Antipsychotic Potential of Some Novel Benzazepines. Journal of Pharmaceutical Sciences and Pharmacology 2 (2), 123-133.
Mahesh Shidore, Jatin Machhi et al., (2015) 3-Substituted 1-methyl-3-benzazepin-2-ones as 5-HT 2C receptor agonists. RSC Advances 5 (111), 91908-91921.
Ashish M Kanhed, Anshuman Sinha, Jatin Machhi et al., (2015) Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis. Bioorganic chemistry 61, 7-12.
Jatin Machhi and N. N. Shah, (2012) Study of antiatherosclerotic activity of polyherbal preparation using rat as an experimental animal model. International Journal Of Pharmaceutical Sciences And Research 3 (10), 4010.

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Dr. Jatin Machhi

Journal of Biomedical Research and Reviews

Department of Pharmacology and Experimental Neuroscience

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