Abstract:

Side effects of the Conventionally used chemotherapies and the limited cell-permeability of the drugs owe to find out the most efficient strategies for the cancer treatment. In the recent years combi-nation of compounds with limited  cell-permeability  with ef?cient delivery systems to minimize side effects and enhance cell-permeability is the area of interest for the formulators. Cell penetrating peptides (CPPs) have the ability to cross the cell membrane which is the obstacle of the delivery of the various anticancer molecules.  limited  cell-permeability of the drugs results into the low bioavailability  which limits the biological application of the anticancer drugs. CPPs are able to internalize in nearly all cell types in vitro and in vivo, while the transport of cargos is virtually possible without any size restriction. Due to high specificity and low toxicity profile, pharmaceutical companies offer viable alternatives to small molecule therapeutics. In this review we have discussed the challenges of the cpp as drug delivery and the applications of the CPP as compared to other Conventionally used chemotherapies.