Dr. Ali (Cyrus) Banan

International Journal of Endocrinology Research

Medicine and Physiology

Name: Dr. Ali (Cyrus) Banan

Educational Qualification: PhD

Designation: Professor of Medicine and physiology at University of South Carolina School of Medicine

Department: Medicine and Physiology

University of South Carolina School of Medicine

Email: cyrusbanan@charter.net

Research Interests: Gastroenterology, Digestive diseases, Medicine, Physiology, Biomedical Sciences, Pharmacology, Personalized Health Care, Translatonal Medicine.

Biography: Dr. Ali (Cyrus) Banan is a founding Head of the Departmental Research and Education at RUSH Chicago Medical School in Illinois, and Founding Head of the University Wide Research and Education at the USC Medical School Greenville South Carolina. He has well over 20 years of extensive experiences at executive and administrative levels in the industry and academia. He has a proven track-record of successfully leading global and national research and education strategies. Dr. Banan has served on over 50 professional committees and over 100 national and international organizations, volunteer boards, government/public health councils, industry, and academia. He has been principal investigator for more than 100 grants, including over $200 million in direct costs alone. He has secured well over $350 million of research and education funding, including from private industry, NIH, CDC, HHS, DARPA, and venture capital. He is also the author of 300+ peer-reviewed publications, book chapters and abstract presentations as well as inventor of several worldwide patents. At Windsor University, he is the second-highest ranking officer of the university, providing academic leadership for the university’s colleges, campuses, research institutes, while overseeing academic support services and student services, and responsibility for curriculum, academic planning, faculty appointments, faculty development and promotion, and tenure decisions among many other responsibilities.

Abstracts

Banan A, J-Y.Wang, and L.R. Johnson. Polyamines effect actin skeleton during the process of gastric mucosal healing. The FASEB Journal: 1474, April 1995.
Banan A, G. S. Smith, E.R. Kokoska, and T.A. Miller. Prostaglandins cytoprotect a human colonic carcinoma cell line against injury: role of microtubule cytoskeleton. Gastroenterology, Vol:112, NO.4 A64, April 1997.
Banan A, G. S. Smith, E.R. Kokoska, and T.A. Miller. Dm-PGE2 Protects a Human Intestinal cell Line (Caco-2) Against Ethanol Injury by stabilizing the cytoskeleton Via Protein Kinase C and Enhanced Calcium Efflux. Gastroenterology, Vol:112, NO.4 A64 (2nd), April 1997.
Banan A, G. S. Smith, E.R. Kokoska, and T.A. Miller. Importance of Actin Cytoskeleton in Prostaglandin Induced Protection Against injury in an Intestinal Epithelial cell Line, IEC-6. The FASEB Journal: 1277, April1997.
E. R. Kokoska, G. S. Smith, A. Banan A, and T.A. Miller. Cytoprotection in A Human Gastric Cell Line. The FASEB Journal: 1270, April 1997.
E. R. Kokoska, A. Banan A, G. S. Smith, and T.A. Miller. Calcium homeostasis and cell mortality in human gastric cells (AGS) exposed to deoxycholate (DC): role of endogenous prostaglandins. Surgical Forum, May 1997.
E. R. Kokoska, A. Banan A, G. S. Smith, and T.A. Miller. Adaptive Cytoprotection (ACP) by Bile Salts in A Human Gastric Cell Line. Gastroenterology, Vol:112, NO.4 A179, April 1997.
E. R. Kokoska, A. Banan A, G. S. Smith, and T.A. Miller. Calcium Accumulation Precedes Cell Death by Deoxycholate (DC) in Human Gastric Cells. Gastroenterology, Vol:112, NO.4 A179 (2rd), April 1997.
E. R. Kokoska, G. S. Smith, A. Banan A, and T.A. Miller. The Role of Calcium and Prostaglandins in Adaptive Cytoprotection. Gastroenterology, Vol:112, NO.4 A179 (3rd), April 1997.
G.S. Smith, M.L. Boyce, D.S. Crouch, G.A. Vogler, A. Banan A, T.A. Miller. A Simplified Method for Studying Hypoxia and Reoxygenation Injury Under In Vitro Conditions. Journal of FASEB:1672, April 1997.
Banan A, G. S. Smith, and T.A. Miller. Role of the Actin Cytoskeleton in Protection by Epidermal Growth Factor and Transforming Growth Factor-a against Aspirin-induced Damage to Human Gastric Cells In Vitro. Gastroenterology, Vol:114, G0260, 1998.
Banan A, G. S. Smith, and T.A. Miller. Role of protein kinase C and calcium efflux in protection by growth factors against aspirin-induced injury in a human gastric cell line. Gastroenterology, Vol:114, G0259, 1998.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Ethanol induced-barrier dysfunction is mediated by inducible-nitric oxide synthase in a human intestinal cell line: role of microtubule oxidation, nitration, and disassembly. Gastroenterology, Vol:116: G0593, 1999.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Role of the microtubule cytoskeleton in protection by growth factors against oxidative barrier disruption in a human colonic cell line. Gastroenterology Vol: 116 G2364, 1999.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Growth factor protection against ethanol-induced microtubule disruption and barrier dysfunction in a human intestinal cell line: Prevention of oxidation, nitration, and disassembly of tubulin. Gastroenterology Vol:116 G3727, 1999.
Banan A, L. Fitzpatrick, S. Choudhary, and A. Keshavarzian. Protective effect of rebamipide and related drugs on oxidative barrier disruption in a human intestinal cell line: Mechanism of beneficial actions. Gastroenterology Vol:116 G2905, 1999.
Mark Kennedy, Heather Decker, Kirin Kumar, A. Banan A, and A. Keshavarzian. Role of Actin Cytoskeletal Disruption in Barrier Dysfunction by Reactive Nitrogen Metabolites in a Human Colonic Cell Line. Gastroenterology Vol:116 G3244, 1999.
Banan A, Y. Zhang, S. Choudhary, and A. Keshavarzian. Protection against oxidative barrier dysfunction by growth factors in a human colonic cell line: role of G- & F-actin cytoskeleton. Central Society for Clinical Research (CSCR): 218A, 1999.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Peroxynitrite-induced Nitration & Oxidation in Cytoskeletal Instability & Loss of Intestinal Epithelial Barrier Function (BF). Gastroenterology 118 (4, pt 1): 4265, 2000.
S. Kommandori, A. Banan A, Y. Zhang, and A. Keshavarzian. Role of cGMP Signal Pathway in Oxidant-Induced Disruption of Actin Cytoskeleton and of Intestinal Barrier Permeability in Human Epithelial cells. Gastroenterology 118 (4, pt 1): 3832, 2000.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Protein Kinase C (PKC) Is Required for The Protective Effects of Growth Factors (GF) on Microtubule Cytoskeleton & Intestinal Epithelial Barrier Integrity (BI). Gastroenterology 118 (4, pt 1), 2000.
Y. Zhang, A. Banan A, R. Hutte, and A. Keshavarzian. Increased Oxidation and Nitration Injury in Intestinal Mucosa of Patients with Inflammatory Bowel Disease. Gastroenterology 118 (4, pt 1): 4266, 2000.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Growth Factors Protect against Intestinal Epithelial Hyperpermeability by Stabilizing Microtubules: Role of Protein Kinase C Signal Activation and Calcium homeostasis. Gastroenterology 118 (4, pt 1): 2365, 2000.
Banan A, S. Choudhary, Y. Zhang, R. Hutte, and A. Keshavarzian. Increased Nitric Oxide Concentrations in the Intestinal Mucosa of Patients with IBD as Detected by a Novel Chemiluminescence Method. Gastroenterology 118 (4, pt 1): 684, 2000.
Banan A, Y. Zhang, S. Choudhary, R. Hutte, and A. Keshavarzian. Ethanol-Induced Intestinal Barrier Dysfunction Is Mediated Through NO Overproduction and Peroxynitrite (ONOO) Generation. Gastroenterology 118 (4, pt 1): 4336, 2000.
Y. Zhang, T. Rodell, T. Murphy, A. Banan A, S. Choudhary, and A. Keshavarzian. Orally Administered Glutathione Peroxidase-Mimetic (BXT-51072) is a potent anti-oxidant: protection against oxidation & nitration of inflamed colonic mucosa in patients with Ulcerative Colitis. Gastroenterology 118 (4, pt 1): 3054, 2000.
Banan A, J.Z. Fields, Y. Zhang, Ece Mutlu, and A. Keshavarzian. Protein Kinase C (PKC)-b1 Mediates EGF-Induced Protection of the Microtubule (MT) Cytoskeleton & Intestinal Barrier Function (BF) against Oxidant Injury. Gastroenterology 120 (No 5, Suppl 1): 3783, 2001.
A Banan A, S Kommandori, J. Z. Fields, Y. Zhang, and A. Keshavarzian. Increased cGMP levels Mediate Oxidant-Induced Disruption of the Microtubule Cytoskeleton & Increased Permeability of Monolayers of Human intestinal Cells. Gastroenterology 120 (No 5, Suppl 1): 3748, 2001.
A Banan A, J.Z. Fields, Y. Zhang, Ece Mutlu, and A. Keshavarzian. Protein Kinase C-b1 Could Explain How EGF Protects the Assembly of the F-Actin Cytoskeleton & the Stability of Intestinal Barrier Integrity (BP) against Oxidants. Gastroenterology 120 (No 5, Suppl 1): 2563, 2001.
A Banan A, J.Z. Fields, Y. Zhang, Ece Mutlu, and A. Keshavarzian. Oxidation & Nitration Injury of Key Cytoskeletal Proteins in Colonic Mucosa of Inflammatory Bowel Disease (IBD) Patients. Gastroenterology 120 (No 5, Suppl 1): 1433, 2001.
Farhadi, A Banan A, Leo Fitzpatrick, J. Z. Fields, Y. Zhang, and A. Keshavarzian. Rebamipide attenuates neutrophil oxidative burst & oxidant generation in the presence or absence of plasma or rectal dialysates from patients with inflammatory bowel disease (IBD). Chicago Society of Gastroenterology. Apr 2001.
A Banan A, Y. Zhang, J.Z. Fields, and A. Keshavarzian. iNOS Upregulation & Actin Nitration Could Explain How Oxidants Disrupt the F-Actin Cytoskeleton & Cause Hyperpermeability (HP) of Intestinal Monolayers. Gastroenterology 120 (No 5, Suppl 1): 1145, 2001.
Banan A, J.Z. Fields, Y. Zhang, Ece Mutlu, and A. Keshavarzian. Pharmacological and Targeted Molecular inhibition of PLC-g Prevents EGF-Mediated Protection of Microtubule (MT) Cytoskeleton & Intestinal Barrier Function (BF). Gastroenterology 120 (No 5, Suppl 1): 3786, 2001.
Banan A, S. Kommanduri, J.Z. Fields, and A. Keshavarzian. Elevated cGMP levels Could Explain How Oxidants Disrupt Microtubule (MT) Cytoskeleton and Increase Permeability of Epithelial Monolayers. The FASEB Journal, 2638 April 2001.
A Banan A, J.Z. Fields, Y. Zhang, and A. Keshavarzian. Protein Kinase C-b1 mediates EGF’s Protection of Microtubule (MT) Cytoskeleton & Intestinal Barrier Function (BF) against Oxidant Injury. The FASEB Journal, 2589 April 2001.
M. Kaplan, A. Banan A, E. Mutlu, R. Mallavarapu, L. Zhang, and A. Keshavarzian. Protection by Commonly Used Herbs against Oxidant-Induced Cell Injury in a Human Colonic Cell Line. Am J Gastro, Vol 96(9): S296, 2001.
Farhadi, A. Banan A, LF. Fitzpatrick, Y. Zhang, A. Keshavarzian. The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant. Am J Gastro, Vol 96(9): S290, 2001.
Banan A, J.Z. Fields, A. Farhadi, L. Zhang, and A. Keshavarzian. Delta (d) Isoform of PKC (PKC-d) Could Explain How Oxidants Disrupt the Microtubule (MT) Cytoskeleton and Injure Monolayers of Intestinal Epithelia. Gastroenterology (Forum Invited Talk) 122 (No 4, Suppl 1): 771, 2002.
Banan A, J.Z. Fields, A. Farhadi, L. Zhang, and A. Keshavarzian. Zeta (z) Isoform of Protein Kinase C Is a Novel Modulator of Intestinal Barrier Integrity & Cytoskeletal Assembly and Key in Cellular Protection. Gastroenterology (Poster of Distinction) 122 (No 4, Suppl 1): M1132, 2002.
Banan A, A. Farhadi J.Z. Fields, L. Zhang, and A. Keshavarzian. Role of Phospholipase C (PLC) Signaling in EGF Protection of Intestinal Integrity & F-Actin Dynamic Assembly: Requirement for Tyrosine Phosphorylation & Activation of The g1 Isoform of PLC. Gastroenterology 122 (No 4, Suppl 1): T863, 2002.
Banan A, A. Farhadi J.Z. Fields, L. Zhang, and A. Keshavarzian. EGF Protects Intestinal Barrier Integrity (BI) by Stabilizing F-Actin Dynamics: Role of PKC-b1 Isoform Signal Activation and Ca+2 Homeostasis. Gastroenterology 122 (No 4, Suppl 1): S833, 2002.
Banan A, J.Z. Fields, A. Farhadi, L. Zhang, and A. Keshavarzian. EGF Protects Intestinal Barrier Integrity (BI) by Stabilizing Microtubule (MT) Assembly: Role of PKC-zeta (z) Isoform Signaling & iNOS Down-regulation. Gastroenterology 122 (No 4, Suppl 1): M1156, 2002.
R. Moghimi, A. Banan A, S. Kommandori, L. Zhang, and A. Keshavarzian. Oxidant-Induced Injury to Monolayers of Human Intestinal Epithelia: Role of cGMP Pathway in Injury to Myosin Type II Cytoskeleton. Gastroenterology 122 (No 4, Suppl 1): S823, 2002.
Farhadi, A. Keshavarzian, E.W. Holms, L. Zhang, A. Banan A. A novel gas chromatographic method for detection of urinary Sucralose: Application to the assessment of intestinal permeability. Am J Gastro, Vol 97(9): S79-80, 2002.
E. Aniziokoro, A. Farhadi, A. Banan A, M. Bakaitis, and A. Keshavarzian. Susceptibility of the small and large bowel to leakiness is a factor in alcoholics with liver disease. Gastroenterology 122 (No 4, Suppl 1): M1358, 2002.
E. Aniziokoro, L. Zhang, A Banan A, A. Farhadi, and A. Keshavarzian. Endotoxemia and increased TNF-alpha in alcoholic liver disease are essential factors for initiating alcohol-induced liver damage. Am J Gastro, Vol 97(9): S91, 2002.
Farhadi, S. Jakate, L. Zhang, M. Bakaitis, A. Banan A, A. Keshavarzian. Differing Response of Mucosal mast cells to stress in IBD and Controls. Am J Gastro, Vol 97(9): S253, 2002.
Domm, A. Farhadi, M. Bakaitis, S. Jakate, A. Banan A, A. Keshavarzian. Intestinal mast cell activation and degranulation following physiological stress in IBD: Electron Microscopy Study. Am J Gastro, Vol 97(9): S255-6, 2002
Banan A, A. Farhadi, J. Z. Fields, L. Zhang, and A. Keshavarzian. Stimulated Human Neutrophils (PMN) Cause The Disassembly & Instability of Cytoskeleton and Disruption of Barrier Integrity (BI) of Human Intestinal Epithelia. Digestive Disease World (Gastroenterology) Conference, Orlando, May 2003.
Banan A, A. Farhadi, J.Z. Fields, L.J. Zhang, M. Shaikh, and A. Keshavarzian. Evidence that NF-kB Activation is Critical to Oxidant Disruption of Cytoskeleton & Barrier integrity (BI) and that its Inactivation is key to EGF Protection of Monolayers of Intestinal Epithelia. Gastroenterology (Forum Invited Talk), 124 (4, supp1): 858, 2003.
Banan A, M. Shaikh, L.J. Zhang, A Farhadi, S. Kommanduri, E. Mutlu, and A. Keshavarzian. Upregulation of NF-kB, (IkBa.P), iNOS, and Cytoskeletal Protein Oxidation and Dysfunction in Colonic Mucosa of Patients with Inflammatory Bowel Disease (IBD). Gastroenterology, 124 (4, supp1): S1338, 2003.
Banan A, A. Farhadi, L.J. Zhang, M. Shaikh, J.Z. Fields, and A. Keshavarzian. Key role of Phospholipase C-g1 Isoform in EGF Protection of F-Actin Cytoskeleton & Intestinal Barrier Integrity (BI) against Oxidant-Induced iNOS Upregulation. Gastroenterology, 124 (4, supp1): M1122, 2003.
Banan A, J.Z. Fields, L.J. Zhang, M. Shaikh, A. Farhadi, and A. Keshavarzian. Atypical Lambda (l) Isoform of PKC (PKC-l) Is a Novel Mediator of Intestinal Barrier Disruption & Cytoskeletal Disassembly and Essential in Oxidative Cellular Injury. Gastroenterology (Poster of Distinction), 124 (4, supp1): M1126, 2003.
Banan A, L.J. Zhang, A. Farhadi, M. Shaikh, E. Mutlu, J.Z. Fields, S. Cotler, and A. Keshavarzian. Increase in iNOS, Free Radicals and Cytoskeletal Protein Oxidation & Nitration in Intestinal Mucosa of Patients with Alcoholic Liver Disease (ALD). Gastroenterology, 124 (4, supp1): M1633, 2003.
G. Swanson, A. Farhadi, A. Banan A, E. Mutlu, S. Cotler, and A. Keshavarzian. Increase in Urinary Neoptrin in Alcoholic Liver Disease after Aspirin Challenge as a Signal of Altered Intestinal Permeability. Gastroenterology, 124 (4, supp1): M1634, 2003.
Banan A, J.Z. Fields, A. Farhadi, M. Shaikh, L.J. Zhang, and A. Keshavarzian. The Novel Delta (d) Isoform of PKC Causes iNOS & NO Upregulation: A Unique Mechanism for Oxidant-induced Carbonylation & Disassembly of the Cytoskeleton and Disruption of Barrier of Intestinal Epithelia. Gastroenterology, 124 (4, supp1): T906, 2003.
Banan A, A. Farhadi, J.Z. Fields, M. Shaikh, L.J. Zhang, and A. Keshavarzian. Zeta (z) Isoform of PKC is a Unique Modulator of NF-kB / I-kB-a in the Intestinal Epithelium & Critical to Monolayer Protection. Gastroenterology (Poster of Distinction), 124 (4, supp1): T1044, 2003.
Farhadi A, E. Sotil, M. Sheikh, A. Banan A, A. Keshavarzian. Is mucosal mast cell in subjects with inflammatory bowel disease different from healthy controls? Am J Gastro 98(9, supp1), S254, 2003.
Farhadi, A. Banan A, Zhang L, Keshavarzian A. Colonic Mucosal Protein Oxidation Induced by Cold Pressor Stress Test in Patients with Inflammatory Bowel Disease; A Possible Contributing Factor in the Pathogenesis and disease flare-up. Am J Gastro 98(9, supp1), S253-4, 2003.
Farhadi, Jakate S, JZ Fields, L. Zhang, A. Banan A, A. Keshavarzian. A New Approach to Intestinal Morphometric Studies: Application to the Assessment of Mucosal Mast Cell Population Size. Am J Gastro 98(9, supp1), S253, 2003.
Farhadi, JZ Fields, M. Shaikh, A. Banan A, A. Keshavarzian. Exaggerated Response to Physiological Stress in Patients with IBD; A Possible Contributing Factor in the Pathogenesis of IBD. Am J Gastro 98(9, supp1), S253, 2003.
Farhadi, Banan A A, Fields JZ, Shaikh M, Holmes EW, Keshavarzian A. Commonly used sugars Interfering with Testing for Intestinal Permeability. Am J Gastro 99(10, supp2), S59, 2004.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Fundamental role of NF-kB Activation in Oxidant-induced iNOS Driven Reactions & Oxidative Stress Injury to Cytoskeleton and Barrier Integrity (BI) of Intestinal Epithelium. Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Fields JZ, Farhadi A, Zhang L, Keshavarzian A. Zeta (z) & Delta (d) Isoforms of PKC Modulate Intestinal Barrier Function (BF) in Opposing Direction: Molecular Modulation of Tight-Junctional Occludin. Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Theta (q) Isoform of PKC Is A New Modulator of Cytoskeletal Dynamics And A Novel Regulator of Intestinal Monolayer Barrier Function (BF) in Epithelial Cells. Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Farhadi A, Fields JZ, Zhang L, Shaikh M, Keshavarzian A. Gamma 1 (g1) isoform of Phospholipase C Uniquely Modulates NF-kB / I-kB-a and Is Key to EGF Protection of Monolayers of Intestinal Epithelium. Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Shaikh M, Zhang L, Farhadi A, Fields JZ, Keshavarzian A. Activation of NF-kB pathway (NF-kB Inducing Kinase /NIK, I-kB kinase /Ik-K, I-kBa, NF-kB subunits) And Cytoskeletal Protein Instability in The Mucosa of Patients With Inflammatory Bowel Disease (IBD). Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Shaikh M, Zhang L, Farhadi A, Fields JZ, Keshavarzian A. Changes in Activity of Distinct PKC isoforms - PKC-Zeta and PKC-Delta - Could Explain the Extent of Oxidative Injury & NF-kB Activation in Mucosa of Patients with Inflammatory Bowel Disease (IBD). Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Classical Beta 1 (-b1) Isoform of PKC Is A Novel Modulator of NF-kB / I-kB-a and Crucial To EGF Protection of Cytoskeletal Assembly and Barrier Function (BF) in Intestinal Monolayers. Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
Banan A, Zhang L, Shaikh M, Farhadi A, Fields JZ, Keshavarzian A. Atypical Lambda (l) Isoform of PKC Is A unique Mediator of F-Actin Cytoskeletal Disassembly & Instability and Key in Oxidative Damage to Monolayers of intestinal cells. Poster of Distinction Presentation in 104th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2004 New Orleans, LA.
CB. Forsyth, Keshavarzian A, Farhadi A, Banan A A. Regulation of intestinal permeability by oxidative and environmental stress via a common metalloproteinase-epidermal growth factor receptor pathway. Gastroenterology, 128 (4, supp2): T1728, 2005.
CB. Forsyth, Keshavarzian A, Choudhary S, Banan A A. Regulation of intestinal permeability via a MMP-EGF- receptor pathway. Forum Invited Talk Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Delta Isoform of PKC (PKC-Delta) Is Critical in the Molecular Disruption of the Intestinal Tight-Junctional Cytoarchitecture and of monolayer barrier function: A unique Mechanism for Epithelial Injury by Oxidant Stress. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Critical Role of the Atypical Lambda Isoform of PKC (PKC-Lambda) in Disruption of the Cytoskeletal Assembly in Monolayers of Intestinal Epithelium. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Unique Role of NF-kB Activation in Disruption of Tight-Junctional Proteins (Occludin) and Monolayer Barrier Integrity; NF-kB Inactivation during Protection of GI Epithelium. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. Theta Isoform of PKC (PKC-Theta) Alters Barrier Function in Intestinal Epithelium through Modulation of Distinct Claudin Isotypes: A Novel Mechanism for Regulation of Tight-Junctional Permeability. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Shaikh M, Zhang L, Farhadi A, Fields JZ, Keshavarzian A. Alterations in NF-kB Signaling (NIK»I-kK»IkB-alpha»NF-kB subunits) Could Explain the Extent of Barrier Tight-Junctional Oxidation & Instability in Mucosa of Patients With Inflammatory Bowel Disease (IBD): A Novel Mechanism for the Pathophysiology of IBD. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Shaikh M, Zhang L, Farhadi A, Fields JZ, Keshavarzian A. Changes in Distinct PKC isoforms – Upregulation of Atypical PKC-Lambda and Downregulation of Classical PKC-Beta-1 Predict Tissue Oxidative Stress and NF-kB Activation in Mucosa of Patients with Inflammatory Bowel Disease (IBD). Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, Zhang L, Farhadi A, Shaikh M, Fields JZ, Keshavarzian A. PKC-Zeta Mediates EGF-Induced Protection through Suppression of NF-kB / I-kK-Beta: A Novel Growth Factor Repair Mechanism in Intestinal Epithelium. Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, L. Zhang L, M. Shaikh, A. Farhadi, A. Keshavarzian. Key Role of PKC-Delta Isoform in Disruption of Tight-Junctional Occludin in Monolayers of Intestinal Epithelium. Poster of Distinction Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, M. Shaikh, A. Keshavarzian. Zeta Isoform of PKC Is A Unique Modulator of the I-kB Kinase-Beta (I-kK-Beta) Pathway and Is Crucial to Monolayer Protection by EGF: A Novel Anti-inflammatory Mechanism in Intestinal Epithelium. Forum Invited Talk Presentation in 105th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2005 Chicago, IL.
Banan A, L. Zhang, M. Shaikh, C.B. Forsyth, J.Z Fields, A. Keshavarzian. Activation Of PKC-b1 Isoform – A Novel Mechanism For The Beneficial Effects Of Lactobacillus GG (LGG) On Monolayers Of Intestinal Epithelial Cells. Forum Invited Talk at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, M. Shaikh, L. Zhang, E. Mutlu, A. Farhadi, J.Z. Fields, A. Keshavarzian. A Translational Strategy Suggests a Future Direction for Inflammatory Bowel Disease (IBD) Therapy: Changes in Tissue & Cellular Lambda (l) Isoform of PKC May Underlie Oxidative Stress & Inflammatory Processes in Intestinal Mucosa. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, M. Shaikh, L. Zhang, J.Z. Fields, E. Mutlu, A. Farhadi, C.B. Forsyth, A. Keshavarzian. Alterations in I-kappa B Kinase (I-kK) Pathways Predict the Instability of Mucosal Claudin Isotypes (1-5) in Patients with Inflammatory Bowel Disease: A Novel Gut Barrier Dependent Mechanism for The Pathophysiology of Human IBD. Poster of Distinction Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, P. Engen, L. Zhang, M. Shaikh, J.Z. Fields, A. Keshavarzian. Ginkgo Biloba Is a Potent Anti-inflammatory Agent in Intestinal Epithelium: Therapeutic Potential for Suppression of NF-kB activation and I-kB degradation. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, P. Engen, L. Zhang, M. Shaikh, A. Keshavarzian. Ginkgo Biloba Protects Against Intestinal Epithelial Barrier Hyperpermeability by Stabilizing Tight-Junctional Proteins: Role of NF-kB Inactivation, Occludin and Claudin. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields, A. Farhadi, C.B. Forsyth, A. Keshavarzian. The Lambda (l) Isoform of PKC Is A Unique Modulator of Inducible NO Synthase (iNOS) Signaling and Is Critical to Monolayer Disruption by Oxidative Stress: A Novel Pro-Inflammatory Mechanism in Intestinal Epithelium. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, M. Shaikh, L. Zhang, E. Mutlu, A. Farhadi, C.B. Forsyth, A. Keshavarzian. A Unique Inflammatory Mechanism in Man: Dysregulation of an EGF-R and PKC Isoform [PKC-z, PKC-b1] Dependent Pathway Appears To Underlie Mucosal Oxidative Stress, NF-kB Activation and Gut Injury in Inflammatory Bowel Disease (IBD). Poster of Distinction Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields, A. Farhadi, C.B. Forsyth, A. Keshavarzian. Protein Kinase C-Delta (PKC-d) Isoform Is a Key Regulator of NF-kB and Its Endogenous Modulator I-kB During Oxidative Stress Injury: A Crucial Pro-Inflammatory Mechanism in Gut Epithelium. Forum Invited Talk at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, L. Zhang, M. Shaikh, C.B. Forsyth, J.Z. Fields, A. Keshavarzian. PKC-b1 activation is required for Epidermal Growth Factor (EGF) Induced Cellular Migration and Cytoskeletal Remodeling in Enterocyte Monolayers: A Unique Wound Healing Mechanism in GI Epithelium. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, M. Shaikh, A. Keshavarzian. Novel Effects of PKC-Lambda (PKC-l) Isoform Activation on Intestinal Monolayers: Carbonylation and Nitration of Cytoskeletal Proteins and Cytoskeletal and Barrier Disruption Following NO Generation in Intestinal Epithelium. Presented at 106th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2006 Los Angeles, CA.
Farhadi, A. Keshavarzian, S. Jakate, M. Shaikh, J.Z. Fields, A. Banan A. Reduced c-kit receptors in mucosal mast cells of IBD patients is not due to mast cell overactivation. Presented at Annual Meeting of the American College of Gastroenterology (ACG), Oct 2006 Las Vegas, NV.
Farhadi, C.B. Forsyth, P. Engen, A. Banan A, A. Keshavarzian. Evidence that a novel, non-chemical, non-electrical intercellular signaling system causes oxidative cytoskeletal damage in distant epithelial cells: Application to modulation of intestinal barrier integrity. Presented at Annual Meeting of the American College of Gastroenterology (ACG), Oct 2006 Las Vegas, NV.
Farhadi, C.B. Forsyth, P. Engen, A. Banan A, A. Keshavarzian. A novel non-chemical, non-electrical intercellular signaling system causes oxidative-induced changes in cell protein content and NF-κB activation in distant epithelial cells. Gastroenterology, 130 (4, supp2): T1167, 2006.
C.B. Forsyth, A. Banan A, Y. Tang, A. Keshavarzian. Ethanol Stimulates EGF-R Mediated MMP Production by Intestinal Epithelial cells. Research Society on Alcoholism (RSA) Alcoholism Clin & Exp Res, 31 (6): 351, 2007.
J. Rangan, C.B. Forsyth, S. Jakate, A. Farhadi, A. Banan A, A. Keshavarzian. Oats Supplementation Prevent Alcohol-Induced Gut Leakiness by Preventing Alcohol-Induced Oxidative Stress in Rat. Research Society on Alcoholism (RSA) Alcoholism Clin & Exp Res, 31 (6): 349, 2007.
J. Rangan, A. Farhadi, M. Sahikh, C.B. Forsyth, A. Banan A, A. Keshavarzian. Leaky Gut And Gut Derived Endotoxin Is Required for Alcoholic Steatohepatitis (ASH) in Rats. Research Society on Alcoholism (RSA) Alcoholism Clin & Exp Res, 31 (6): 348, 2007.
Lau, A. Farhadi, M. Shaikh, A. Banan A, A. Keshavarzian. Upregulation of human intestinal iNOS by Alcohol as a mechanism of oxidative stress in alcoholic liver disease. Research Society on Alcoholism (RSA) Alcoholism Clin & Exp Res, 31 (6): 106, 2007.
Y. Tang, A. Banan A, C.B. Forsyth, H.P. Nissan, M. Shaikh, L. Zhang, J. Rangan, P. Engen, A. Keshavarzian. Melatonin and colon carcinogenesis: inhibitory effect of melatonin on oxidant (H2O2 )-induced β-catenin accumulation. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, L. Zhang, M. Shaikh, C.B. Forsyth, Y. Tang, A. Farhadi, A. Keshavarzian. Changes in Activity of The Zeta (ζ) Isoform of PKC Is an Important Determinant of The Inflammatory Pathways: Unique Protective & Modulatory Mechanisms in Gut Epithelium. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, L. Zhang, M. Shaikh, Y. Tang, C.B. Forsyth, A. Keshavarzian. A New physiological Mechanism for Epithelial Migration & Monolayer Healing: PKC-Lambda (PKC-λ) Isoform Activity Is Required for Oxidant-Induced Reduction of Cellular Migration And Remodeling in Gut. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, L. Zhang, M. Shaikh, C. B. Forsyth, Y. Tang, A. Keshavarzian. Activation Of PKC-λ (Lambda) Isoform Could Explain The Proinflammatory And Non-Beneficial Effects of Bacterial Flagellin (FLG) on Monolayers Of Intestinal Cells: A Distinct PKC-dependent, Bacterial-Induced, Injurious Mechanism in Epithelium. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Lau, A. Farhadi, M. Shaikh, A. Banan A, A. Keshavarzian. Alcohol induced up regulation of human intestinal iNOS: possible mechanism of oxidative stress in alcoholic liver disease (ALD). Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, J. Rangan, A. Fardadi, M. Shaikh, C. B. Forsyth, Y. Tang, L. Zhang, A. Keshavarzian. Critical Role of NO Overproduction and Oxidative Stress (Nitration, Carbonylation) In Increased Gut Barrier Leakiness In An Animal Model of Alcoholic-Liver Disease (ALD). Forum Invited Talk at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, M. Shaikh, L. Zhang, C. B. Forsyth, A. Farhadi, E. Mutlu, Y. Tang, A. Keshavarzian. A Unique Inflammatory Mechanism for Intestinal Injury During IBD: Modulation of A Distinct Phospholipase C-γ1 (PLC-γ1) Dependent Pathway Could Underlie EGF-Receptor Initiated Events That Lead To Mucosal Oxidative Stress And NF-κB Activation In Man. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Lau, A. Farhadi, M. Shaikh, A. Banan A, A. Keshavarzian. Aspirin challenge unveils susceptibility to colonic hyper-permeability in subjects with alcoholic liver disease. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, L. Zhang, M. Shaikh, C. B. Forsyth, Y. Tang, A. Farhadi, A. Keshavarzian. A Crucial Anti-inflammatory & Barrier Protective Mechanism in Gut Epithelium: PKC-Zeta (ζ) Isoform Is A Key Player in Protection of Cellular Structural Components and Is a Novel Modulator of the I-kB Kinase (I-kK) -α and -β Isotype Pathways. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
B. Forsyth, A. Banan A, A. Farhadi, D. Hayden, A. Keshavarzian. Chemokine Receptor CXCR4 in IBD Patients May Contribute to Progression to Cancer by Stimulating EGF-R Signaling and Metalloprotease Expression. Forum Invited Talk Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, M. Shaikh, L. Zhang, J. Z. Fields, E. Mutlu, A. Farhadi, C. B. Forsyth, A. Keshavarzian. Alterations Of PLC-γ1–PKC Isoform Pathway And The I-kappa B Kinase (I-kK)—NFkB Pathway Predict The Extent Of Mucosal Barrier Protein Isotype Instability in Man: A Novel Barrier Dependent Mechanism For Oxidation And IBD Pathophysiology. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, P. Engen, L. Zhang, M. Shaikh, C. B. Forsyth, Y. Tang, A. Keshavarzian. Novel Therapies Against Inflammation Using Botanical Dietary Supplements – Scuttelaria Baicalensis Is a Potent Suppressor of NF-kB Pathway: Anti-inflammatory Potential via Prevention of I-kB Degradation in Intestinal Epithelium. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, L. Zhang, M. Shaikh, Y. Tang, C. B. Forsyth, A. Keshavarzian. Inactivation Of The Atypical PKC-Lambda (PKC-λ) Isoform Enhances Cellular Migration And Cytoskeletal Remodeling in Enterocyte Monolayers: A Novel Wound Healing Mechanism in Epithelium. Presented at 107th Annual Meeting of the American Gastroenterological Association (Digestive Disease Week) May, 2007 Washington, DC.
Banan A, R. Turpin, K. Williams, M. Reynolds. Bloodstream Infection Rates, Length of Stay, and Costs Associated with Compounded versus Multi-chamber Bag Parenteral Nutrition in Gastrointestinal Surgical Patients. Presented at Annual Meeting of American College of Gastroenterology (P264) October, 2009; San Diego, CA.
A Banan A, T. Pavlina, G. Zaloga, K. Harvey, R. Saddiqui. Oleic acid prevents stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. Presented at Annual Meeting of Experimental Biology (A106 / 4551), Los Angeles, CA, 2010.

Banan A, J-Y. Wang, S. A. McCormack, and L.R. Johnson.Relationship between polyamines, actin distribution, and gastric mucosal ulcer healing in rats. American Journal of Physiology Vol. 34/No. 5 (GI & Liver): G893-G903, 1996.
Banan A, S. A.McCormack, and L.R. Johnson. Polyamines are required for microtubule formation during gastric mucosal ulcer healing. American Journal of Physiology Vol. 274/No. 37 (GI & Liver): G879-G885, 1998.
Banan A, G. S. Smith, E. R. Kokoska, and T.A. Miller. Protection against ethanol injury by prostaglandins in a human intestinal cell line: role of microtubules. American Journal of Physiology 274/No. 37 (GI & Liver): G111-G121, 1998.
Banan A, G. S. Smith, E. R. Kokoska, and T.A. Miller. Prostaglandins protect human intestinal cells against ethanol injury by stabilizing microtubules: Role of protein kinase C and enhanced calcium efflux. Digestive Diseases & Sciences, 44 (No. 4): 697-707, 1999.
R. Kokoska, G. S. Smith, A. Banan A, and T.A. Miller. Adaptive cytoprotection against deoxycholate-induced injury in human gastric cells in vitro: is there a role for endogenous prostaglandins? Digestive Diseases & Sciences, 43 (No. 4): 806-815, 1998.
R. Kokoska, G. S. Smith, A. Banan A, and T.A. Miller. Disturbed calcium homeostasis and injury in human gastric cells exposed to Ethanol: role of endogenous prostaglandins. Surgical Forum, Vol. XLVIII, p. 166-168, 1998.
E.R. Kokoska, G.S. Smith, A. Banan A, and T.A. Miller. The role of calcium in adaptive cytoprotection and cell injury induced by deoxycholate in a human gastric cell line. American Journal of Physiology, 275 (2 pt 1): G322-30, 1998.
Banan A, S. Choudhary, Y. Zhang, J.Z. Fields, and A. Keshavarzian. Ethanol-Induced Barrier dysfunction and its Prevention by Growth Factors in Human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms. Journal of Pharmacology & Experimental Therapeutics, 291(3): 1075-1085, 1999.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Ethanol induces microtubule oxidation, nitration, and disassembly and disrupts barrier function in a human intestinal cell line. Alcoholism Clinical & Experimental Research, 23 (5): 669, 1999.
S. Choudhary, S. Yong, A. Banan A, and A. Keshavarzian. Effect of oats on alcohol induced liver disease. Alcoholism Clinical & Experimental Research, 23 (5): 660, 1999.
Banan A, G. S. Smith, E. R. Kokoska, and T.A. Miller. Role of actin cytoskeleton in prostaglandin-induced protection against ethanol in an intestinal epithelial cell line, IEC-6. Journal of Surgical Research, 88: 104-113, 2000.
Banan A, S. Choudhary, Y. Zhang, and A. Keshavarzian. Role of the microtubule cytoskeleton in protection by epidermal growth factor and transforming growth factor-a against oxidant-induced barrier disruption in a human colonic cell line. Free Radical Biology and Medicine, 28(5), 727-738, 2000.
Banan A, Y. Zhang, J. Losurdo, and A. Keshavarzian. Carbonylation and disassembly of the F-actin cytoskeleton in oxidant-induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor-α in a human intestinal cell line. Gut (British Journal of Gastroenterology), 46: 830-837, 2000.
Banan A, J.Z. Fields, Y. Zhang, Heather Decker, and A. Keshavarzian. Nitric Oxide and Its Metabolites Mediate Ethanol-Induced Microtubule Disruption and Intestinal Barrier Dysfunction. Journal of Pharmacology and Experimental Therapeutics, 294 (3), 997-1008, 2000.
T.A. Miller, G.S. Smith, A. Banan A, and E.R. Kokoska. Cytoskeleton as a Target for Injury in Damaged Intestinal Epithelium. Microscopy Research & Technique, 51(2): 149-55, 2000.
Banan A, L. Fitzpatrick, Y. Zhang, and A. Keshavarzian. OPC-Compounds Prevent Oxidant-Induced Carbonylation and Depolymerization of The F-Actin Cytoskeleton and Intestinal Barrier Hyperpermeability. Free Radical Biology and Medicine, 30(3), 287-298, 2001.
Banan A, Y. Zhang, J.Z. Fields, and A. Keshavarzian. Key role of PKC and Calcium Homeostasis in Epidermal growth Factor-Induced Protection of the Microtubule Cytoskeleton and Intestinal Barrier against Oxidant Injury. American Journal of Physiology (GI & Liver), 280: G828-G843, 2001.
Banan A, J.Z. Fields, Y. Zhang, and A. Keshavarzian. iNOS Upregulation Mediates Oxidant-Induced Disruption the F-Actin Cytoskeleton and Permeability Barrier of Monolayers of Intestinal Epithelia. American Journal of Physiology (GI & Liver), 280: G1234-G1246, 2001.
S. Choudhary, A. Keshavarzian, M. Wade, and A. Banan A. Novel Antioxidants Zolimid and AEOL 11201 Ameliorate Colitis in Rats. Digestive Diseases and Sciences. Digestive Diseases & Sciences, Vol. 46 (10): 2222-30, 2001.
Banan A, J.Z. Fields, D.A Talmage, Y. Zhang, and A. Keshavarzian. The b1 Isoform of Protein Kinase C Mediates Epidermal Growth Factor-Induced Protection of the Microtubule Cytoskeleton and Intestinal Monolayer Barrier Function against Oxidant Injury. American Journal of Physiology (GI and Liver), 281: G833-G847, 2001.
Banan A, Y. Zhang, J.Z. Fields and A. Keshavarzian. Targeted Molecular inhibition of PLC-g Prevents EGF-Mediated Protection of Microtubule Cytoskeleton & Intestinal Barrier Function. American Journal of Physiology (GI and Liver), 281: G412-G423, 2001.
Keshavarzian, S. Choudhary, A. Banan A, and J.Z. Fields. Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. Journal of Pharmacology & Experimental Therapeutics, 299 (2), 442-448, 2001.
T.A. Miller, E.R. Kokoska, G.S. Smith, and A. Banan A. Role of calcium homeostasis in gastric mucosal injury and protection. Life Sci, 69(25-26): 3091-102, 2001.
A Farhadi, J.Z. Fields, A. Banan A, and A. Keshavarzian. Reactive Oxygen Species: Are they involved in the pathogenesis of GERD, Barrett’s Esophagus, and latters progression towards esophageal cancer? American J. Gastroenterology, Vol 97(1): 22-26, 2002.
Farhadi, A. Keshavarzian, L.F. Fitzpatrick, and A. Banan A. The Modulatory Effects of Plasma and Colonic Milieu of Patients with Ulcerative Colitis on Human PMN Oxidative burst: Therapeutic Efficacy of OPC Anti-Oxidants. Digestive Diseases & Sciences, 47(6): 1342-1348, 2002.
Banan A, J. Z. Fields, D.A Talmage, L. Zhang, and A. Keshavarzian. A Protective role for Protein Kinase C: The Atypical PKC-Zeta (z) Is Required for the Protection of the Microtubule Cytoskeleton and Barrier Integrity of Human Intestinal Monolayers Against Oxidants. American Journal of Physiology (GI & liver), 282: G794-G808, 2002.
Banan A, L. Zhang, J. Z. Fields, D.A. Talmage, and A. Keshavarzian. PKC-z Prevents Oxidant-induced iNOS Upregulation and Protects microtubules and Intestinal barrier integrity. American Journal of Physiology (GI & liver), 283: G909-G922, 2002.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Protein Kinase C-b1 Mediates the Protective effects of Epidermal Growth Factor on the Dynamic Assembly of the F-actin Cytoskeleton and Normalization of Calcium Homeostasis in A Human Colonic Cell Line. Journal of Pharmacology & Experimental Therapeutics, 310:852-866 2002.
Banan A, L. Zhang, A. Farhadi, J.Z. Fields, and A. Keshavarzian. Activation of the Delta (d) Isoform of PKC (PKC-d) Is Required for Oxidant-Induced Disruption of both the Microtubule Cytoskeleton and Permeability Barrier of Intestinal Epithelia. Journal of Pharmacology & Experimental Therapeutics, 303:17-28, 2002.
Keshavarzian, A. Banan A, S. Kommandori, A. Farhadi, Y. Zhang, and J.Z. Fields. Increases in Colonic Free Radicals and in Cytoskeletal Protein Oxidation and Nitration in The Colonic Mucosa of Patients with Inflammatory Bowel Disease. British Journal of Gastroenterology (Gut), 52(5): 720-728, 2003.
Farhadi, A. Banan A, J.Z. Fields, and A. Keshavarzian. Intestinal Barrier: An interface Between Health and Disease. Journal of Gastroenterology & Hepatology, 18(5):479-497, 2003.\
Banan A, L. Zhang, J.Z. Fields, and A. Keshavarzian. The Novel Delta (d) Isoform of PKC Causes iNOS & NO Upregulation: A Key Mechanism for Oxidant-induced Carbonylation, Nitration, and Disassembly of the Microtubule Cytoskeleton and Hyperpermeability of Barrier of Intestinal Epithelia. Journal of Pharmacology & Experimental Therapeutics, 305(2):482-94, 2003.
Farhadi, A. Keshavarzian, E.W. Holmes, J.Z. Fields, Zhang, A. Banan A. Gas Chromatographic Method for Detection of Urinary Sucralose: Application to the Assessment of Intestinal Permeability. J Chromatography B Analyt Technol Biochem, 784(1):145-54, 2003.
Farhadi, A. Banan A A. Keshavarzian. Role of Cytoskeletal Structures in Modulation of Intestinal Permeability. Arch Iranian Med J. (AIMJ), 6(1):49-53, 2003.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Evidence That NF-kB Activation Is Critical in Oxidant-Induced Disruption of The Microtubule Cytoskeleton & Barrier Integrity and That Its Inactivation Is Essential in EGF-Mediated Protection of The Monolayers of Intestinal Epithelia. Journal of Pharmacology & Experimental Therapeutics, 306(1): 13-28, 2003.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Key role of Role of Phospholipase C-gamma (PLC-g) Isoform in EGF Protection of Epithelial Barrier against iNOS upregulation and F-actin Nitration and Disassembly. American Journal of Physiology (Cell Physiology), 285(4): C977-C993, 2003.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Zeta (z) Isoform of Protein Kinase C Prevents Oxidant-Induced NF-kB Activation and I-kBa Degradation: A Fundamental Mechanism for EGF Protection of The Microtubule Cytoskeleton and Intestinal Barrier Integrity. Journal of Pharmacology & Experimental Therapeutics, 307(1): 53-66, 2003.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Requirement for The Classical PKC isoform beta 1 (PKC-b1) signaling in the Suppression of the NF-kB / I-kBa Proinflammatory Pathway and in Protection of Cell Monolayer Barrier by EGF Under Conditions of Oxidative Stress. American Journal of Physiology (Cell Physiology), 286(3):C723-38, 2004.
Banan A, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Key role of Phospholipase C-g1 Isoform as An Upstream Signal in EGF-mediated Suppression of both NF-kB Activation and I-kBa degradation and Protection of Intestinal Monolayers. Journal of Pharmacology & Experimental Therapeutics, 309(1):356-68, 2004.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Theta (q) Isoform of Protein Kinase C (PKC-q) Is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: A new function for PKC-Theta. American Journal of Physiology (Cell Physiology), 287(1):C218-34. 2004.
Banan A, L. Zhang, J.Z. Fields, M. Shaikh, A. Farhadi and A. Keshavarzian. Novel effect of NF-kappaB activation: NO Upregulation and carbonylation and nitration injury to cytoskeleton in intestinal epithelium. American Journal of Physiology (Cell Physiology), 287(4):C1139-51, 2004.
Banan A, M. Shaikh, L. Zhang, J.Z. Fields, A. Farhadi, and A. Keshavarzian. Atypical Lambda (l) Isoform of PKC (PKC-l) Is Another Novel Mediator in Oxidant-induced loss of Monolayer Barrier Function and Cytoskeletal Assembly in Intestinal Epithelium. Journal of Pharmacology & Experimental Therapeutics; 312(2):458-71, 2005.
Banan A, L. Zhang, J.Z. Fields, and A. Keshavarzian. Theta (q) Isoform of PKC Alters Barrier Function in Intestinal Epithelium through Modulation of Distinct Tight-Junctional Claudin Isotypes: A Novel Mechanism for Regulation of Permeability. J Pharmacology & Experimental Therapeutics, 313(3):962-82, 2005.
J. Ren, A. Banan A, A. Keshavarzian, Q. Zhu, N. LaPaglia, J. McNulty, N.V. Emanuele, and M.A, Emanuele. Exposure to ethanol induces oxidative damage in the pituitary gland. Alcohol, 35(2):91-101, 2005.
Farhadi, A. Keshavarzian, D.L. Van de Kar, J.Z. Fields, and A. Banan A. Heightened responses to stressors in patients in inflammatory bowel disease. Am J. Gastroenterology 100(8):1796-804, 2005.
Farhadi, A. Keshavarzian, J.Z. Fields, and A. Banan A. Role of PKC Isoforms in Modulation of the Repair Processes of Intestinal Barrier. J Pharmacology & Experimental Therapeutics, 316(1):1-7, 2006.
Farhadi, A. Keshavarzian, J.Z. Fields, M. Shaikh, and A. Banan A. Resolution of common dietary sugars from probe sugars for test of human intestinal barrier permeability using capillary column gas chromatography. J Chromatography (J Chromatography B Analyt Technol Biomed Life Sci.) 19:836(1-2):63-8, 2006.
C.B. Forsyth, A. Banan A, A. Farhadi, M. Shaikh, L.J. Zhang, P. Engen, and A. Keshavarzian. Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. J Pharmacology & Experimental Therapeutics. 321(1):84-97, 2007.
Farhadi, A. Banan A, C.B. Forsyth, M. Shaikh, L.J. Zhang, and A. Keshavarzian. Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cells. Bioelectrochemistry, 71(2):142-8, 2007.
Banan A, L.J. Zhang, J.Z. Fields, M. Shaikh, C.B Forsyth, Y. Tang, and A. Keshavarzian. Alcohol-Induced NF-kappaB activation: A unique mechanism for Gut Barrier disruption in monolayer epithelium. Alcohol, 41(6):447-60, 2007.
Keshavarzian, E. Mutlu, JP. Guzman, CB. Forsyth, A. Banan A. Emerging Therapies In Inflammatory Bowel Disease. Expert Opin Investig Drugs. 16(9):1489-506, 2007.
M. Kaplan, E. Mutlu, M. Benson, A. Keshavarzian, A. Banan A. Use of herbal preparations in the treatment of oxidant-mediated inflammatory disorders. Complement Ther Med., 15(3):207-16, 2007.
Farhadi, A. Keshavarzian, JZ. Fields, S. Jakate, M. Shaikh, A. Banan A. Reduced c-kit receptors in mucosal mast cells in inflammatory bowel disease. J Gastroenterol Hepatol., 22(12):2338-43, 2007.
Y. Tang, A. Banan A, CB. Forsyth, JZ. Fields, CK. Lau, LJ. Zhang, A. Keshavarzian. Effect of oxidative stress on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res. 32(2):355-64, 2008.
Y. Tang, CB. Forsyth, A. Farhadi, J. Rangan, S. Jakate, M. Shaikh, A. Banan A, JZ. Fields, and A. Keshavarzian. Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage. Alcohol Clin Exp Res. 33(7):1220-30, 2009.
Y. Tang, CB. Forsyth, A. Banan A, JZ. Fields, and A. Keshavarzian. Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage. J Pharmacol Exp Ther. 329(3):952-8, 2009.
Keshavarzian, A. Farhadi, CB. Forsyth, J. Rangan, S. Jakate, M. Shaikh, A. Banan A, and JZ. Fields. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol. 50(3):538-47, 2009.
N. Azarpira N, S. Namazi, F. Hendijani F, A. Banan A, and M. Darai. Investigation of allele and genotype frequencies of CYP2C9, CYP2C19 and VKORC1. Pharmacol Rep. 62(4):740-6, 2010.
E. Esmaeilzadeh-Gharehdaghi, A. Banan A, S. Farashi, A. Mirabzadeh, T. Farokhashtiani, S. Hosseinkhani, A. Heidari, H. Najmabadi, and M. Ohadi. Support for down-tuning of the calreticulin gene in the process of human evolution. Prog Neuropsychopharmacol Biol Psychiatry. 35(7):1770-3, 2011.
Heidari, Z. Nariman Saleh Fam, E. Esmaeilzadeh-Gharehdaghi, A. Banan A, S. Hosseinkhani, S. Mohammadparast, M. Oladnabi M, H. Najmabadi, and M. Ohadi. Core promoter STRs: novel mechanism for inter-individual variation in gene expression in humans. Gene. 492(1):195-8, 2012.
Banan A, E. Esmaeilzadeh-Gharehdaghi, Z. Nezami M, Deilami, S. Farashi, S. Philipsen, F. Esteghamat, F. Pourfarzad, and Najmabadi H. cAMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells. Clin Exp Pharmacol Physiol. 39(6):510-7, 2012.
Heidari, S. Hosseinkhani, S. Talebi, R. Meshkani, E. Esmaeilzadeh-Gharedaghi, A. Banan A, H. Darvish, and M. Ohadi. Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: implication in degenerative disorders. Gene. 505(1):186-9, 2012.
Banan A, H. Bayat, A. Azarkeivan, S. Mohammadparast, K. Kamali, S. Farashi, N. Bayat, MH. Khani, M. Neishabury, and H. Najmabadi. The XmnI and BCL11A single nucleotide polymorphisms may help predict hydroxyurea response in β-thalassemia patients. Hemoglobin. 36(4):371-80, 2012.
E. Valipour, A. Kowsari, H. Bayat, A. Banan A, S. Kazeminasab, S. Mohammadparast, and M. Ohadi. Polymorphic core promoter GA-repeats alter gene expression of the early embryonic developmental genes. Gene. 531(2):175-9, 2013.
PM. Frew, S. Zhang, DS. Saint-Victor, AC. Schade, S. Benedict, A. Banan A, X. Ren, and SB. Omer. Influenza vaccination acceptance among diverse pregnant women and its impact on infant immunization. Hum Vaccin Immunother. 9(12):2591-602, 2013.
R. Pazhoomand, E. Keyhani, A. Banan A, H. Najmabadi, F. Khodadadi, A. Iraniparast, and F. Behjati. Detection of HER2 status in breast cancer: comparison of current methods with MLPA and real-time RT-PCR. Asian Pac J Cancer Prev. 14(12):7621-8, 2013.
Asgharian, A. Banan A, and H. Najmabadi H. Optimizing A Lipocomplex-Based Gene Transfer Method into HeLa Cell Line. Cell J. 5(4):372-7, 2014.
F. Larti, K. Kahrizi, L. Musante, H. Hu, A. Banan A, M. Garshasbi, TF Wienker, and H. Najmabadi. A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive disability. Eur J Hum Genet. 2014 Feb 26.
Banan A, LJ. Zhang, J.Z. Fields. Upregulation of NF-kB Pathways and Cytoskeletal Protein Disassembly & Dysfunction in Mucosal Tissues of Patients with Inflammatory Bowel Disease. GUT, 2015.
Banan A, LJ. Zhang, M. Shaikh. Ginseng Protects Against Mucosal Epithelial Hyperpermeability by Stabilizing Barrier function Proteins: Role of NF-kB, Claudins & Microtubules. Am J Physiology (Cell Physiol), 2015.
Banan A, M. Shaikh, LJ. Zhang, JZ. Fields. Alterations in I-kappa B Kinase (I-kK) Pathways Predict the Instability of Mucosal Barrier Function Proteins in Patients with IBD: A Novel Tight-Junctional Dependent Mechanism for The Pathophysiology of Human IBD. GUT, 2015.
Banan A, LJ. Zhang, M. Shaikh, JZ. Fields. A Mixture of Herbs Ginseng, Chinese Skullcap, and Rosemary Is a Potent Anti-oxidant and anti-inflammatory in vivo in mice and in vitro in Mucosal Epithelium: Therapeutic Potential for Suppression of NF-kB activation and barrier Instability. J Pharmacol Exp Ther., 2015.
Banan A, M. Shaikh, LJ. Zhang, Y. Tang. Evidence That Novel Transcription Factor NURR-1 is Crucial in Cytoskeletal Instability and Damage in Intestinal Epithelium. J. Biological Chemistry, 2015.
Banan A, Y. Tang, M. Shaikh, LJ. Zhang. Cutting-Edge: Generation of An Intestinal Epithelial Cell specific PKC-λ Knockout Transgenic Mice and its Applications for Understanding Gut Inflammation. J Clinical Invest.,2015.
Banan A, LJ. Zhang, M. Shaikh. Unique Pathophysiological Effects of PKC-l Isoform Activation: Upregulation of iNOS, NO and Oxidation & Nitration of Cytoskeleton and Barrier Proteins in Intestinal Epithelium. Am J Physiol (Cell Physiol), 2015.
Y. Tang, A. Banan A, F. Preuss. Sleep Deprivation Worsens Dextran Sodium Sulfate-Induced Colitis in Mice. Gut, 2015.
Banan A, L. Zhang, J.Z. Fields. Zeta (z) Isoform of PKC Is A Unique Modulator of the I-kB Kinase beta (I-kK-b) Pathway and Is Crucial to Monolayer Protection by EGF: A Novel Anti-inflammatory Mechanism in Intestinal Epithelium. American Journal of Physiology (Cell Physiology).
C.B. Forsyth, A. Banan A, A. Farhadi, J.Z. Fields, Y. Tang, M. Shaikh. Alcohol Stimulates Expression of SNAIL-1, Metalloprotease-EGF-R Signaling, and Markers of Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells. Cancer Research, 2015 (To be submitted).
Banan A, M. Shaikh, L. Zhang, J.Z. Fields. Assessment of the PKC Isoform activation, NF-kB Activation and I-kBa Degradation in Patients with Inflammatory Bowel Disease. GUT, 2015.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields. The Atypical PKC-z and Novel PKC-d Isoforms Modulate Tight-Junctional Protein Occludin and Barrier Permeability In Opposing Direction in Intestinal Epithelium. American Journal of Physiology (Cell Physiology), 2015.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields, A. Farhadi. Protein Kinase C-Delta (PKC-d) Isoform Is a Key Regulator of NF-kB and Its Endogenous Modulator I-kB During Oxidative Stress Injury: A Crucial Pro-Inflammatory Mechanism in Gut Epithelium. Journal of Pharmacology & Experimental Therapeutics, 2015.
S. Kommandori, A. Banan A, J. Z. Fields, L. Zhang. Increased cGMP levels Mediate, in Part, Oxidant-Induced Disruption of the Actin Cytoskeleton & Increased Permeability of Monolayers of Human intestinal Cells. Journal of Pharmacology & Experimental Therapeutics, 2015 (To be submitted).
Banan A, L. Zhang, J.Z. Fields, and A. Keshavarzian. Atypical Lambda (l) PKC (PKC-l) Causes the F- and G- Actin Oxidation and Instability and Monolayer Hyperpermeability through Upregulation of NO Driven Reactions. Molecular Pharmacology, 2015.
Banan A, S. Kommandori, R. Mogimi, J.Z. Fields, L. Zhang. Oxidant-Induced Disruption of the Microtubules and Hyperpermeability of Monolayers of Human Intestinal Cells: Role of G Kinase (PKG) Signaling. American Journal of Physiology (GI & Liver), 2015.
Banan A, L. Zhang, M. Shaikh, C.B. Forsyth, J.Z. Fields. Activation of PKC-b1 Isoform – A Novel Mechanism for The Beneficial Effects Of Bacterial Lactobacillus GG (LGG) On Monolayers of Intestinal Epithelial Cells. European Journal of Cell Biology, 2015.
Banan A, M. Shaikh, L. Zhang, J.Z. Fields, A. Farhadi. Changes in Distinct PKC isoforms – Upregulation of atypical PKC-Lambda and Downregulation of classical PKC-Beta-1 – Predict Tissue Oxidative Stress and NF-kB Activation in Mucosa of Patients with Inflammatory Bowel Disease (IBD). Journal of Pharmacology & Experimental Therapeutics, 2015.
Banan A, L. Zhang, P. Engen, J.Z. Fields, A. Farhadi. Upregulation of Novel Transcription Factors, Inflammatory Pathways, and Cytoskeletal Protein Disassembly & Dysfunction in Mucosal Tissues of Patients with Inflammatory Bowel Disease. GUT, 2015.
Banan A, L. Zhang, M. Shaikh, J.Z. Fields. Delta (d) Isoform of PKC (PKC-d) Is Critical in the Molecular Disruption of the Intestinal Tight-Junctional Cytoarchitecture and of Monolayer Barrier Function: A Unique Mechanism for Epithelial Barrier Protein Instability by Oxidant Stress. American Journal of Physiology (GI & Liver Physiology), 2015.
Forsyth CB, A. Banan A, A. Farhadi, J.Z. Fields, Y. Tang, M. Shaikh, L.J. Zhang. Alcohol Stimulates Intestinal Permeability through Metalloprotease (MMP)-Mediated Epidermal Growth Factor (EGF) Receptor Signaling. Alcohol Clin Exper Research, 2015.
Banan A, L. Zhang, J.Z. Fields. I-kB Kinase beta (I-kK-b) Isotype is a Key Determinant of Monolayer Injury and Protection: An EGF Dependent Model for Regulation of Tight Junctional Barrier in Intestinal Epithelium. American Journal of Physiology (Cell Physiology), 2015.
Banan A, CB Forsyth, L. Zhang, J.Z. Fields. Oxidative stress activates ErbB- ¾ growth factor signaling and Induces Intestinal Hyper-permeability: Key Role of ErbB-3 and ErbB-4 Receptors in Intestinal Barrier Homeostasis. Cell, 2015.
Banan A, M. Shaikh, L. Zhang, A. Farhadi. A Unique Inflammatory Mechanism in Man: Dysregulation of an EGF-R and PKC Isoform [PKC-z, PKC-b1] Dependent Pathway Also Appears To Underlie Mucosal Oxidative Stress, NF-kB Activation and Gut Injury in Inflammatory Bowel Disease (IBD). American Journal of Physiology (GI & Liver), 2015.
Banan A, L. Zhang, C.B. Forsyth, M. Shaikh, J.Z. Fields. PKC-b1 and PKC-l are required for Epidermal Growth Factor (EGF) Induced Cellular Migration and Cytoskeletal Remodeling in Enterocyte Monolayers: A Unique Wound Healing Mechanism in Epithelium. J Clinical Investigation, 2015.
Banan A A, Farhadi A, Forsyth CB, Keshavarzian A. Protein oxidation, intestinal barrier and Inflammatory Bowel Disease. Protein Oxidation and Disease. Recent Research Developments in Pathological Biochemistry, 2006, Rossendorf Research Center, Dresden, Germany.
Farhadi A, Banan A A, Forsyth CB, Keshavarzian A. Protein oxidation, intestinal barrier and Alcoholic Liver Disease. Protein Oxidation and Disease. Recent Research Developments in Pathological Biochemistry, 2006, Rossendorf Research Center, Dresden, Germany.
Farhadi A, Banan A A, Fields JZ, Keshavarzian A. Alcohol and intestinal permeability. Implication for human toxicity. Reviews in Food and Nutrition Toxicity, 2003, Taylor and Francis Book Ltd, London, UK.
Farhadi A, Fields JZ, Banan A A, Keshavarzian A. Is the concentration of reactive oxygen species produced in Barrett’s mucosa a contributor to malignant transformation? Barrett's Esophagus, 6th Vol. 2001. John Libbey Eurotext. International Organization for statistical Studies on Diseases of the Esophagus (O.E.S.O), Paris, France.

Serial no:IIEBM0514

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Dr. Ali (Cyrus) Banan

International Journal of Endocrinology Research

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