Dr. Huan Bao

International Journal of Immunological Research and Reviews

Biochemistry & Molecular Biology

Name: Dr. Huan Bao

Educational Qualification: Ph.D.

Designation: Assistant Professor

Department: Biochemistry & Molecular Biology

Scripps Research-Florida

Email: hbao@scripps.edu

Research Interests: Membrane protein, Biochemistry, Enzymology, Single-molecule biophysics, Vesicular transport, Protein engineering.

Biography: Dr. Huan Bao was originally from Wuhan, China. He obtained B.S. from the Wuhan University and then did his Ph.D. at the University of British Columbia in Vancouver, Canada. After a postdoc training at HHMI/UW-Madison, he became an assistant professor at the Scripps Research Institute at Jupiter, Florida

Bradberry MM, Bao H, Lou X, Chapman ER. (2019) PIP2 drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β. J Biol Chem., in press.
Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. (2019) Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A., in press.
Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. J Gen Physiol., in press.
Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. (2018) Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods 11: 936-939.
Bao H, Das D, Courtney N, Jiang Y, Briguglio J, Lou X, Roston D, Cui Q, Chanda B and Chapman ER. (2018) Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties. Nature 554: 260-263.
Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER and Bellen HJ. (2017) The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Rep. 21(13):3794-3806.
Fabre L, Bao H, Innes J, Duong F and Rouiller I. (2017) Negative-stain single particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE and maltose. J Biol Chem. 292(13): 5457-64.
Carlson ML, Bao H, and Duong F. (2016) Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter. J Biol Chem. 291(23): 12119-25.
Bai H, Xue R, Bao H, Zhang L, Yethiraj A, Cui Q and Chapman ER. (2016) Different states of synaptotamin regulate evoked versus spontaneous release. Nat Commun. 22(7): 10971.
Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM and Chapman ER. (2016) Exocytotic fusion pores are composed of both lipids and proteins. Nat Struct Mol Biol. 23(1): 67-73. (Cover paper)
Bao H, Dalal K, Cytrynbaum E and Duong F. (2015) Sequential action of substrate and binding protein allows coupling of ATP hydrolysis to translocation in the maltose ABC importer. J Biol Chem. 290(42): 25452-60.
Bao H and Duong F. (2014) Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation. J Biol Chem. 289(14):9844-51.
Bao H and Duong F. (2013) Anionic lipid phosphatidylglycerol directs binding and inhibition of EIIAGlc onto the maltose transporter. J Biol Chem. 288(33): 23666-74.
Bao H, Dalal K, Wang V, Rouiller I and Duong F. (2013) The maltose ABC transporter: action of membrane lipids on the transporter stability, coupling and ATPase activity. Biochim Biophys Acta. 1828(8): 1723-30.
Bao H and Duong F. (2013) ATP alone triggers the outward-facing conformation of the maltose ABC transporter. J Biol Chem. 288(5): 3439-48.
Bao H, Duong F and Chan CS. (2012) A step-by-step method for the reconstitution of an ABC transporter into Nanodiscs Lipid Particles. J Vis Exp 66: e3960.
Bao H and Duong F. (2012) Discovery of an auto-regulation mechanism for the maltose transporter MalFGK2. Plos One. 7(4): e34836.
Chan CS, Zhang XX, Bao H, Foster LJ, and Duong F. (2012) Nanodiscs and SILAC-based mass spectrometry to identify a membrane protein interactome. J Proteome Res. 11(2):1454-9.
Gold VA, Robson A, Bao H, Romantsov T, Duong F, and Collinson I. (2010) The action of cardiolipin on the bacterial translocon. Proc Natl Acad Sci U S A.107 (22): 10044-9.
Dalal K, Bao H, and Duong F. (2010) Modulation of the SecY channel permeability by pore mutations and trivalent cations. Channels (Austin) 4(2): 83-6.

Serial no:IIEBM0597

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Dr. Huan Bao

International Journal of Immunological Research and Reviews

Biochemistry & Molecular Biology

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