Dr. Shuangli MI

International Journal of Cancer and Treatment

Genomic and Precision Medicine

Name: Dr. Shuangli MI

Educational Qualification: Ph.D

Designation: Professor, Principal Investigator at Beijing Institute of Genomics, Chinese Academy of Sciences

Department: Genomic and Precision Medicine

Beijing Institute of Genomics

Email: mishl@big.ac.cn

Research Interests: Epigenetic regulation mechanism of non-coding RNAs in Cancer, Identification of biomarkers for cancer diagnosis or prognosis, Leukemia, Pharmacology, Cancer Genomics.

Biography: Dr. Shuangli Mi is currently working as principal investigator in Beijing Institute of Genomics, Chinese Academy of Sciences. She received her Ph.D. in Peking University, Beijing, China. She got her postdoctoral training in University of Chicago to study the mechanisms for microRNAs regulation in acute leukemia and pharmacogenomics for personalized medicine. She is now focusing on the epigenetic roles of non-coding RNAs including miRNAs and lncRNAs in carcinogenesis and tumor progression and identify novel biomarkers for cancer diagnosis and prognosis.

Organizations and Activities:

2008-2018 Member of the American Society of Hematology (ASH)

2007-2018 Member of the American Association for Cancer Research (AACR)

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, et al. (2018) CRISPR interference-based specific and efficient gene inactivation in the brain. Nature Neuroscience 21(2): 447-454.
Mi S, Klungland A, Yang YG, Base-excision repair and beyond—A short summary attributed to scientific achievements of Tomas. Lindahl, Nobel Prize Laureate in Chemistry 2015. Science China Life Science. 2016, 59(1):89-92.
Mertens J, Wang QW, Kim Y, Yu DX, Pham S, et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 5;527(7576):95-9.
Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi S. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 2015 Feb;13(1):17-24.
Zhu X, He F, Zeng H, Ling S, Chen A, et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014, 46(3):287-93.
Mi S, Zhang J, Zhang W, Huang RS. Circulating microRNAs as biomarkers for inflammatory diseases. MicroRNA. 2013, 2(1): 64-72.
Wen Y, Gamazon ER, Bleibel WK, Wing C, Mi S, McIlwee BE, Delaney SM, Duan S, Im HK, Dolan ME. An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet. 2012, 21(7):1470-1480.
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ. MLL Fusion Proteins Preferentially Regulate a Subset of Wild Type MLL Target Genes in the Leukemic Genome. Blood. 2011, 117(25):6895-6905.
Tao Y, Ruan J, Yeh SH, Lu X, Wang Y, et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. P Natl Acad Sci USA. 2011, 108(29):12042-12047.
Mi S, Li Z, Chen P, He C, Cao D, et al. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. P Natl Acad Sci USA. 2010, 107(8):3710-3715.
Huang RS, Johnatty SE, Gamazon ER, Im HK, Ziliak D, et al. Australian Ovarian Cancer Study Group, Dolan ME. Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin Cancer Res. 2011, 17(16):5490-500.
Stark AL, Zhang W, Mi S, Duan S, O'Donnell PH, et al. Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J. 2010, 10(6):505-512.
Huang RS, Mi S. Candidate genes pharmacogenetics of anti-cancer agents. Pharmacogenomics, 2009, 10(5):719-720.
Hartford C, Duan S, Delaney S, Mi S, Kistner E, Lamba J, Huang RS, Dolan ME. Population Specific Genetic Variants Important in Susceptibility to Cytarabine Arabinoside Cytotoxicity. Blood. 2009, 113(10):2145-2153.
Duan S, Huang RS, Zhang W, Mi S, Bleibel WK, et al. Expression and Alternative Splicing of Folate Pathway Genes in HapMap Lymphoblastoid Cell Lines. Pharmacogenomics, 2009. 10(4):549-563.
Duan S, Mi S, Zhang W, Dolan M.E. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. RNA biology. 2009, 6(4):412-425.
Li Z, Luo RT, Mi S, Sun M, Chen P, et al. Consistent deregulation of gene expression between human and murine MLL-rearrangement leukemias. Cancer Res. 2009, 69(3):1109-1116.
Li Z, Lu J, Sun M, Mi S, Zhang H, et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. P Natl Acad Sci USA. 2008, 105(40):15535-15540.
Mi S, Lu J, Sun M, Li Z, Zhang H, et al. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. P Natl Acad Sci USA. 2007, 104(50):19971-19976.
Wang M, Xie H, Mi S, Chen J. Recent patents on the identification and clinical application of microRNAs and target genes. Recent Patents on DNA & Gene Sequences. 2007, 1(2):116-124.
Zhang XY, Wu Y, Yan JY, Gao Y, Wang Y, Mi SL, An CC. Y55 and D78 are crucial amino acid residues of a new IgE epitope on trichosanthin. Biochem Biophy Res Co. 2006, 343(4):1251-1256.
Mi SL, An CC, Wang Y, Chen JY, Che NY, et al. Trichomislin, a novel ribosome-inactivating protein, induces apoptosis that involves mitochondria and caspase-3. Archives of Biochemistry and Biophysics. 2005, 434(2):258-265.
Wang Y, Mi SL, Lou M, Gao Y, Chen ZL, An CC. Enhanced Green Fluorescence protein tracks Trichosanthin in human choriocarcinoma cells as a feasible and stable reporter. Frontiers in Bioscience. 2005, 10:2279-2284.
Yan Y, An C, Li L, Gu J, Wang L, Mi S, Chen Z. The sense and antisense expression of gibberellin 20-oxidase gene (rga5) in rice and its effects on GA1 level and agronomic traits. Chinese Science Bulletin. 2003, 48(5):443-448.

Serial no:IIEBM0509

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Dr. Shuangli MI

International Journal of Cancer and Treatment

Genomic and Precision Medicine

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