Dr. Suresh Vasu Madathilparambil

International Journal of Endocrinology Research

Department of Surgery

Name: Dr. Suresh Vasu Madathilparambil

Educational Qualification: PhD

Designation: Assistant Research Professor Department of Surgery at University of Michigan

Department: Department of Surgery

University of Michigan

Email: madathil@umich.edu

Research Interests: Alcohol and ARDS, Diabetes Mellitus, Gastric aspiration and ARDS, Hypoglycemia, Pneumonia and ARDS, Lung contusion and ARDS, Role of Basil in Acute Lung Injury, Role of HIF-1/2 alpha in Lung Injury, Role of Toll-like receptors in Lung Injury, Role of curcumin in Acute Lung Injury

Biography: Dr. Suresh Madathilparambil is Assistant Research Professor of Surgery in the Division of Acute Care Surgery, at the University of Michigan Health Systems. He received his Bachelor's and Master's degree in Biology, and his Ph.D. in Biochemistry from the University of Kerala, India. In 2001, he received the Young Scientist Award from the Department of Science & Technology in India. He did his postdoctoral training initially at East Tennessee State University, Tennessee and later at the University of Michigan. In January 2012, He joined the faculty of the Section of General Surgery, University of Michigan Health Systems, as a Research Investigator.

Lal JJ, Kumar CV, Suresh MV, Indira M, Vijayammal PL: Effect of coconut palm wine (Toddy) on carbohydrate Suresh MV metabolism in pregnant rats and fetuses Plant Foods Hum Nutr 50(1): 71-79, 01/1997. PM9198117
Suresh MV, Lal JJ, Kumar S, Indira M: Interaction of ethanol and ascorbic acid on lipid metabolism in guinea pigs Indian J. Exp. Biol. 35(10): 1065-1069, 02/1998. PM9475041
Suresh MV, Lal JJ, Sreeranjit kumar CV, Indira M: Ascorbic acid metabolism in rats and guinea pigs after the administration of ethanol Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 124(2): 175-179, 01/1999. PM10622433
Suresh MV, Sreeranjit Kumar CV, Lal JJ, Indira M: Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs Toxicol. Lett. 104(3): 221-229, 02/1999. PM10079057
Lal JJ, Sreeranjit Kumar CV, Suresh MV, Indira M, Vijayammal PL: Effect of in utero exposure of Toddy Suresh MV (coconut palm wine) on liver function and lipid metabolism in rat fetuses Plant Foods Hum Nutr 52(3): 209-219, 02 /1999. PM9950082
Sreeranjitkumar CV, Lal JJ, Suresh MV, Indira M, Vijayammal PL: Effect of ethanol/arrack on the lipid Suresh MV metabolism of mammary gland during pregnancy and lactation in rats Indian J. Physiol. Pharmacol. 43(3): 332-336, 04/2000. PM10776481
Lal JJ, Kumar CV, Suresh MV, Indira M, Vijayammal PL: Prenatal exposure of an alcoholic beverage (Arrack) on Suresh MV fetal lipid metabolism in rats Indian J. Physiol. Pharmacol. 44(3): 273-280, 08/2000. PM10941614
Suresh MV, Menon B, Indira M: Effects of exogenous vitamin C on ethanol toxicity in rats Indian J. Physiol. Pharmacol. 44(4): 401-410, 02/2001. PM11214494
Lal J, Kumar CV, Suresh MV, Indira M, Vijayammal PL: Effect of exposure to a country liquor (Toddy) during Suresh MV gestation on lipid metabolism in rats Plant Foods Hum Nutr 56(2): 133-143, 04/2001. PM11318502
Sivaram AG, Suresh MV, Indira M: Combined effect of ascorbic acid and selenium supplementation on alcoholSuresh MV induced oxidative stress in guinea pigs Comp. Biochem. Physiol. C Toxicol. Pharmacol. 134(3): 397-401, 03/2003. PM12643986
Suresh MV, Asha G S, Indira M: Effect of exogenous selenium on alcohol induced oxidative stress in rats J. Nutraceuticals functional and medical foods. 4((4)): 53-65., 04/2003. 244923510
Suresh MV, Singh SK, Agrawal A: Interaction of calcium-bound C-reactive protein with fibronectin is controlled by pH: In vivo implications J. Biol. Chem. 279(50): 52552-52557, 12/2004. PM15456743
Suresh MV, Singh SK, Ferguson Jr DA, Agrawal A: Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection J. Immunol. 176(7): 4369-4374, 04/2006. PM16547275
Suresh MV, Singh SK, Ferguson Jr DA, Agrawal A: Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide J. Immunol. 178(2): 1158-1163, 01/2007. PM17202380
Susick L, Veluthakal R, Suresh MV, Hadden T, Kowluru A: Regulatory roles for histone deacetylation in IL-1Suresh MV induced nitric oxide release in pancreatic -cells J. Cell. Mol. Med. 12(5A): 1571-1583, 12/2007. PM18053091
Singh SK, Suresh MV, Prayther DC, Moorman JP, Rusiñol AE, Agrawal A: C-reactive protein-bound Suresh MV enzymatically modified low-density lipoprotein does not transform macrophages into foam cells J. Immunol. 180(6): 4316-4322, 03/2008. PM18322245
Singh SK, Suresh MV, Voleti B, Agrawal A: The connection between C-reactive protein and atherosclerosis Ann. Suresh MV Med. 40(2): 110-120, 05/2008. PM18293141
Singh SK, Suresh MV, Prayther DC, Moorman JP, Rusiñol AE, Agrawal A: Phosphoethanolamine-complexed CSuresh MV reactive protein: A pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum Clin. Chim. Acta 394(1-2): 94-98, 08/2008. PM18486609
Agrawal A, Suresh MV, Singh SK, Ferguson Jr DA: The protective function of human C-reactive protein in mouse Suresh MV models of Streptococcus pneumoniae infection Endocr Metab Immune Disord Drug Targets 8(4): 231-237, 12/2008. PM19075776
Veluthakal R, Suresh MV, McDonald P, Olson LK, Kowluru A: Regulatory roles for Tiam1, a guanine nucleotide Suresh MV exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic -cells Biochem. Pharmacol. 77(1): 101-113, 01/2009. PM18930714
Singh SK, Suresh MV, Hammond Jr DJ, Rusiñol AE, Potempa LA, Agrawal A: Binding of the monomeric form of Suresh MV C-reactive protein to enzymatically-modified low-density lipoprotein: Effects of phosphoethanolamine Clin. Chim. Acta 406(1-2): 151-155, 08/2009. PM19545552
Veluthakal R, Suresh MV, Kowluru A: Down-regulation of expression and function of nucleoside diphosphate Suresh MV kinase in insulin-secreting -cells under in vitro conditions of glucolipotoxicity Mol. Cell. Biochem. 329(1-2): 121129, 09/2009. PM19367376
Narala VR, Adapala RK, Suresh MV, Brock TG, Peters-Golden M, Reddy RC: Leukotriene B is a physiologically Suresh MV 4 relevant endogenous peroxisome proliferator-activated receptor- agonist J. Biol. Chem. 285(29): 22067-22074, 07 /2010. PM20400503
Machado-Aranda DA, Suresh MV, Yu B, Raghavendran K: Electroporation-mediated in vivo gene delivery of the Suresh MV Na /K ATPase pump reduced lung injury in a mouse model of lung contusion J Trauma Acute Care Surg 72(1): + +32-40, 01/2012. PM22310113
Suresh MV, Yu B, Machado-Aranda D, Bender MD, Ochoa-Frongia L, Helinski JD, Davidson BA, Knight PR, Hogaboam CM, Moore BB, Raghavendran K: Role of macrophage chemoattractant protein-1 in acute inflammation after lung contusion Am. J. Respir. Cell Mol. Biol. 46(6): 797-806, 06/2012. PM22281985
Suresh MV, Wagner MC, Rosania GR, Stringer KA, Min KA, Risler L, Shen DD, Georges GE, Reddy AT, Parkkinen J, Reddy RC: Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury Am. J. Respir. Cell Mol. Biol. 47(3): 280-287, 09/2012. PM22312018
Machado-Aranda D, Wang Z, Yu B, Suresh MV, Notter RH, Raghavendran K: Increased phospholipase A and Suresh MV 2 lyso-phosphatidylcholine levels are associated with surfactant dysfunction in lung contusion injury in mice Surgery 153(1): 25-35, 01/2013. PM22853859
*Lakshminrusimha S, Suresh MV, Knight PR, Gugino SF, Davidson BA, Helinski JD, Nielsen LC, Russell JA, *Suresh MV Yu B, Zeng L, Pennathur S, Raghavendran K: Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion. Shock (Augusta, Ga.) 39(3): 278-85, 03/2013. PM23364426/23364426 (*Joint first authors)
Suresh MV, Yu B, Lakshminrusimha S, Machado-Aranda D, Talarico N, Zeng L, Davidson BA, Pennathur S, Raghavendran K: The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion Surgery 154(5): 980-990, 11/2013. PM24139490
Machado-Aranda D, Suresh MV, Yu B, Dolgachev V, Hemmila MR, Raghavendran K: Alveolar macrophage Suresh MV depletion increases the severity of acute inflammation following nonlethal unilateral lung contusion in mice. The journal of trauma and acute care surgery 76(4): 982-90, 04/2014. PM24662861
Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM: Loss of von Suresh MV hippel-lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2 and regulation of bile acid homeostasis Mol. Cell. Biol. 34(7): 1208-1220, 04/2014. PM24421394
Miller DL, Suresh MV, Dou C, Yu B, Raghavendran K: Characterization of ultrasound-induced pulmonary Suresh MV capillary hemorrhage in rats. Microvascular research 93: 42-5, 05/2014. PM24583360
Suresh MV, Ramakrishnan SK, Thomas B, Machado-Aranda D, Bi Y, Talarico N, Anderson E, Yatrik SM, Raghavendran K: Activation of hypoxia-inducible factor-1 in type 2 alveolar epithelial cell is a major driver of acute inflammation following lung contusion. Critical care medicine 42(10): e642-53, 10/2014. PM25014067
Dolgachev VA, Goldberg R, Suresh MV, Thomas B, Talarico N, Hemmila MR, Raghavendran K, MachadoSuresh MV Aranda D: Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia. Gene Ther 23((11)): 785–796, 01/2016. PM27454317
Suresh MV, Thomas B, Dolgachev VA, Sherman MA, Goldberg R, Johnson M, Chowdhury A, Machado-Aranda D, Raghavendran K: Toll-like receptor-9 (TLR9) is requisite for acute inflammatory response and injury following lung contusion Shock 46(4): 412-419, 01/2016. PM26939039
Suresh MV, Thomas B, Dolgachev VA, Sherman MA, Goldberg R, Johnson M, Chowdhury A, Machado-Aranda D, Raghavendran K: Toll-Like Receptor-9 (TLR9) is Requisite for Acute Inflammatory Response and Injury Following Lung Contusion. Shock 46(4): 412-9. d, 09/2016. PM26939039
*Sherman MA, * Suresh MV, Dolgachev VA, McCandless LK, Xue X, Ziru L, Machado-Aranda D, Shah YM, Suresh MV Raghavendran K: Molecular Characterization of Hypoxic Alveolar Epithelial Cells After Lung Contusion Indicates an Important Role for HIF-1. Ann Surg 2016 Nov 1: 1-7, 11/2016. 27811509 (*Joint first authors)
Suresh MV, Thomas B, Machado-Aranda D, Dolgachev VA, Kumar Ramakrishnan S, Talarico N, Cavassani K, Sherman MA, Hemmila MR, Kunkel SL, Walter NG, Hogaboam CM, Raghavendran K: Double-Stranded RNA Interacts with Toll-Like Receptor 3 in Driving the Acute Inflammatory Response Following Lung Contusion Crit. Care Med. 44(11): e1054-e1066, 11/2016. PM27509390
Obi AT, Andraska E, Kanthi Y, Luke CE, Elfline M , Siahaan TJ, Jaffer FA, Wakefield TW, , Suresh MV Raghavendran K, Henke PK: Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis Journal of Vascular Research 53(3-4): 186-195, 12/2016. PM27771726
Dolgachev V, Panicker S, Balijepalli S, McCandless LK, Yin Y, Swamy S, , Delano MJ, Hemmila MR, Suresh MV Raghavendran K, Machado-Aranda D: Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia. Gene Ther 23((11)): 785–796, 01/2018. PM29907877
Hyun Chang Kim, Vikas V. Singh, Davis Q. Arick, David A. Machado-Aranda, Krishnan Suresh MV, Raghavendran, and You-Yeon Won: Polymer Lung Surfactants ACS Appl. Bio Mater 1(3): 581–592, 09/2018. 10.1021/acsabm.8b00061
Suresh MV, Boya Zhang, S Balijepalli, S Panicker, S Swamy, V Dolgachev, D Machado-Aranda, J Parkkinen, K Raghavendran: Water-Soluble Curcumin Complex Administration Reduces Severity of Lethal Pneumonia JLB. (Submitted) (*Corresponding author)
Suresh MV; Sanjay Balijepalli; Vikas Vikram Singh; Boya Zhang; Samantha Swamy; Sreehari Panicker; Vladislav A. Dolgachev; Chitra Subramanian; Sadeesh K Ramakrishnan; Bvin Thomas; Tejeshwar C. Rao; Mathew J. Delano; David Machado-Aranda; Yatrik M. Shah; Krishnan Raghavendran: Hypoxia-Inducible Factor (HIF)-1 is an Important Promoter of Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice EJI. (Submitted)
Sreehari Panicker; Sanjay Balijepalli; Boya Zhang; Matthew A. Sherman; Suresh MV; Krishnan Raghavendran: Suresh MV Role of Toll-like Receptor-9 in Sepsis and Lung Injury JNSCI. (Submitted)
Arundhathy Suresh; Boya Zhang, MS; Tejeshwar C. Rao, Krishnan Raghavendran, MD; Suresh MV: Holy Basil Suresh MV Protects Alveolar Epithelial Cells from Fatal Pneumonia Shock. (Submitted) (*Corresponding author)
Anthony J. Baldea, MD and Fred A. Luchette, MD, MSc: The Role of Hypoxia-Inducible Factor-1 in Response to Injury and Hypoxia, It is with great interest that we read the article by Suresh et al (1) in this issue of Critical Care Medicine, Critical Care Medicine, 2016.

Serial no:IIEBM0555

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Dr. Suresh Vasu Madathilparambil

International Journal of Endocrinology Research

Department of Surgery

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