Email: xiaobinxu1@gmail.com
Research Interests: Mass spectrometry-based therapeutic protein/biomarker quantification, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and chemical cross-linking mass spectrometry for protein conformation and protein-protein interaction studies, post-translational modifications, top-down mass spectrometry, host cell protein identification and quantification, separation of mAbs and mAb fragments, and bioanalytical method development and validation.
Biography: Dr. Xiaobin Xu is a Staff Scientist at Regeneron Pharmaceuticals. He received his B.S. and M.S. in Chemistry from Sichuan University, Chengdu, China. He received his Ph. D. in Prof. Catherine E. Costello’s lab at Boston University, where he focused on proteomics and biological applications of mass spectrometry, especially for characterization of structures, interactions, and functions of proteins. At Regeneron, he leads and performs analytical characterization of therapeutic proteins to support pre-clinical and clinical development. In addition, he develops new analytical methods and technologies to better characterize monoclonal antibodies (mAbs). His research interests include mass spectrometry-based therapeutic protein/biomarker quantification, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and chemical cross-linking mass spectrometry for protein conformation and protein-protein interaction studies, post-translational modifications, top-down mass spectrometry, host cell protein identification and quantification, separation of mAbs and mAb fragments, and bioanalytical method development and validation.
